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Bone strength assessment by finite element and trabecular bone score (TBS) analysis in healthy individuals aged 60 years and older

Grant number: 17/00693-7
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 01, 2017
Effective date (End): October 31, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Rosa Maria Rodrigues Pereira
Grantee:Jackeline Couto Alvarenga Amaral
Supervisor: Steven Boyd
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Calgary, Canada  
Associated to the scholarship:15/14698-5 - Reference curves of bone parameters obtained by high resolution peripheral quantitative computed tomography (HR-PQCT) in healthy men, BP.DR


Osteoporosis and it main consequence, the fracture is a worldwide health public problem. Dual energy X-ray absorptiometry (DXA) is currently the most accepted method for the clinical diagnosis and assessment of fracture risk. However, this technology has limitations, thus, there is a need to study other methods for assess bone quality.Bone parameters obtained by high resolution peripheral quantitative computed tomography (HR-pQCT) together finite element analysis (FE) that computationally predicts bone strength, is increasingly used to assess bone quality, fracture risk, and anti-fracture interventions. Trabecular bone score (TBS) derived from lumbar spine DXA images is a gray-level textural index of bone microarchitecture that predict fracture risk independent of BMD. The aim of this study is to assess the bone strength by FAIM finite element (Bone Imaging Laboratory - Numerics88 Solutions Ltd.) obtained from distal radius and tibia with HR-pQCT, and correlate with TBS derived from lumbar spine in healthy individuals, to improve the prediction of fractures. A total of 300 Brazilian participants aged 60 years and older will be including. To assess bone strength, we will use FAIM finite element (spin-off product from the Bone Imaging Laboratory - Numerics88 Solutions Ltd.) which will be measured from the analysis previously obtained with a HR-pQCT system (XtremeCT, Scanco Medical AG, Brüttisellen, Switzerland). The software for TBS calculation is TBS iNsight® Version 2.1 (Med-Imaps, Bordeaux, France) analyzed by the means of DXA images of the lumbar spine.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVARENGA, J. C.; CAPARBO, V. F.; DOMICIANO, D. S.; PEREIRA, R. M. R.. Age-related reference data of bone microarchitecture, volumetric bone density, and bone strength parameters in a population of healthy Brazilian men: an HR-pQCT study. OSTEOPOROSIS INTERNATIONAL, v. 33, n. 6, p. 13-pg., . (15/14698-5, 17/00693-7)

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