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Functionalized silica nanoparticles: a strategy for Zika virus inactivation

Grant number: 16/21598-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2017
Effective date (End): October 27, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Mateus Borba Cardoso
Grantee:Lívia Mesquita Dias Loiola
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovações (Brasil). Campinas , SP, Brazil
Associated research grant:15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles, AP.TEM
Associated scholarship(s):19/17028-1 - Zika Virus Irreversible Inactivation by Dendritic Copolymers as Broad-Spectrum Antiviral Agents, BE.EP.PD

Abstract

The Zika virus was declared by the World Health Organization a case of global public health emergency in 2016. The Zika virus infection has been associated with microcephaly, with thousands of cases reported only in Brazil. However, viral inactivation strategies that can prompt the treatment of infections and the combat to epidemics associated to the Zika are still scarce. In this context, the development of porous silica nanoparticles (SiO2NPs) as systems that promote viral inactivation, not only by its superficial polymeric coating but also by the encapsulated drug, both presenting antiviral action, is been proposed. Accordingly, polyanions, which are capable to prevent the interaction between virus and target cells, will be polymerized on the surface of SiO2NPs by RAFT controlled radical polymerization. The subsequent polymerization of biocompatible and biodegradable polymeric chains will be used as a strategy to increase time of transit of the particles, avoiding early inactivation of anionic groups in intravenous applications. Furthermore, by the conjugation of zwitterionic groups to these polymeric chains, non-specific adsorption of blood plasma proteins (corona effect), and subsequent immune responses or undesirable side effects, might be avoided. The complex drug carrier systems will therefore be developed during this research project, by the conjugation of functional polymer segments on the SiO2NPs surface. Their structural and morphological properties, in addition to their biological activity, anti-viral outcome and preventive action to the corona effect, will be evaluated. Thereby, considering the recent increasing number of cases and the lack of specific medical treatments, the development of drug-loaded SiO2NPs presenting polymeric coatings with anti-viral action consist of a potential alternative to Zika virus inactivation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOIOLA, LIVIA M. D.; BATISTA, MARINA; CAPELETTI, LARISSA B.; MONDO, GABRIELA B.; ROSA, RHUBIA S. M.; MARQUES, RAFAEL E.; BAJGELMAN, MARCIO C.; CARDOSO, MATEUS B.. Shielding and stealth effects of zwitterion moieties in double-functionalized silica nanoparticles. Journal of Colloid and Interface Science, v. 553, p. 540-548, . (17/09203-2, 15/25406-5, 16/21598-0, 17/01167-7, 17/06692-2, 16/16905-0)
CAPELETTI, LARISSA BRENTANO; AFFONSO DE OLIVEIRA, JESSICA FERNANDO; DIAS LOIOLA, LIVIA MESQUITA; GALDINO, FLAVIA ELISA; DA SILVA SANTOS, DENYS EWERTON; SOARES, THEREZA AMELIA; FREITAS, RAUL DE OLIVEIRA; CARDOSO, MATEUS BORBA. Gram-Negative Bacteria Targeting Mediated by Carbohydrate-Carbohydrate Interactions Induced by Surface-Modified Nanoparticles. ADVANCED FUNCTIONAL MATERIALS, v. 29, n. 48, . (17/01167-7, 13/22429-9, 15/25406-5, 18/09555-9, 16/21598-0)

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