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Comparing platelet aggregation by VerifyNow P2Y12 and Multiplate ADP in coronary artery disease patients using dual platelet anti aggregation before and after assisted physical training

Grant number: 16/23161-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2016
Effective date (End): November 30, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:José Carlos Nicolau
Grantee:Fernanda Reali de Oliveira
Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:14/01021-4 - Platelet aggregation and antiaggregation in coronary artery disease patients, AP.TEM


Clinical trials in healthy subjects demonstrate that moderate intensity training reduces adhesiveness and platelet agregability at rest and in response to intense physical exercise. Although recent evidence has shown a significant reduction in the recurrence of cardiovascular events with the use of new and more potent antiplatelet agents in coronary patients, its percentage is not negligible, which reinforces the need for additional measures to further decrease these rates. The assessment of platelet aggregation in patients with post-AMI who underwent assisted physical training may clarify the role of exercise in modulating it. (AU)

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