Scholarship 16/23013-9 - Oncologia, Adenocarcinoma

Grant number:	16/23013-9
Support Opportunities:	Scholarships in Brazil - Master
Effective date (Start):	December 01, 2016
Effective date (End):	June 30, 2018
Field of knowledge:	Biological Sciences - Genetics

Principal Investigator:	Vanessa da Silva Silveira
Grantee:	Verena Silva Santos

Host Institution:	Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Associated research grant:	15/10694-5 - Dual specificity phosphatases activity on map kinases signaling regulation: impact on pancreatic ductal adenocarcinoma metabolic reprogramming, AP.JP


Abstract Given the difficulty to find specific drugs which can treat pancreatic ductal adenocarcinoma (PDAC) efficiently, this project aims to identify molecular targets that may sensitize pancreatic cancer cells to gemcitabine. To achieve this goal and provide additional information regarding PDAC biology, this project will investigate the negative feedback mechanisms involved in MAPK signaling activation mediated by Dual-specificity phosphatases (DUSPs). Therefore, it proposes to evaluate whether the modulation of specific DUSPs presents any sensitizing potential against gemcitabine in pancreatic adenocarcinoma cell lines. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Verena Silva. Effect of DUSP11 modulation on gemcitabine sensitivity in pancreatic ductal adenocarcinoma cell lines. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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