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Wnt and Ca2+ signaling in normal and leukemic hematopoietic stem cell fate

Grant number: 16/23787-4
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 27, 2017
Effective date (End): March 26, 2018
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal researcher:Edgar Julian Paredes-Gamero
Grantee:Marina Mastelaro de Rezende
Supervisor abroad: Reinoud Gosens
Home Institution: Instituto Nacional de Farmacologia (INFAR). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Research place: University of Groningen, Netherlands  
Associated to the scholarship:15/24464-1 - Subcellular Ca2+ signaling aspects in proliferation control of haemopoietic stem cells by interleukin-3 and granulocyte/macrophage colony stimulating factor, BP.DR


Hematopoiesis is the process in which cells from the lymphatic and hematopoietic systems are formed, starting from precursor cells that have multipotency and self-renewal capabilities - the hematopoietic stem cells (HSCs). Appropriate mature progeny maintenance and production requires numerous cellular mechanisms related to HSC proliferation and differentiation, where cytokines act as direct modulators. Alterations in such processes may lead to cellular dysfunctions and the development of a leukemic phenotype, characterizing the leukemic stem cells (LSC). Recently, our group showed the ubiquitous Ca2+ signaling role in HSC and LSC proliferation, differentiation as well as cell death, yet, how small and oscillatory variations in intracellular Ca2+ concentrations, elicited by cytokines, modulate HSC responses is still unknown. Wnt signaling has been recently associated with HSC fate regulation and intracellular Ca2+ variations. Therefore, we aim to investigate the crosstalk between Ca2+ and Wnt signaling during HSC and LSC fate, using techniques, such as single cell analysis and transfection of HSC and LSC.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE REZENDE, MARINA MASTELARO; NG-BLICHFELDT, JOHN-POUL; JUSTO, GISELLE ZENKER; PAREDES-GAMERO, EDGAR JULIAN; GOSENS, REINOUD. Divergent effects of Wnt5b on IL-3-and GM-CSF-induced myeloid differentiation. CELLULAR SIGNALLING, v. 67, . (15/16799-3, 15/24464-1, 16/23787-4)
DE REZENDE, MARINA MASTELARO; FERREIRA, ALICE T.; PAREDES-GAMERO, EDGAR J.. Leukemia stem cell immunophenotyping tool for diagnostic, prognosis, and therapeutics. Journal of Cellular Physiology, . (15/24464-1, 16/23787-4)

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