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Study of the chemical behaviour of metallodrugs of diruthenium(II,III) containing anti-inflammatories

Grant number: 16/23028-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2017
Effective date (End): June 30, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal researcher:Denise de Oliveira Silva
Grantee:Marcio Hayashi
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


In the context of the Bioinorganic Chemistry, special attention has been dedicated to the investigation of metal complexes with potential application in pharmacology/medicine. Diruthenium compounds containing non-steroidal anti-inflammatory drugs (NSAIDs) have been subject of study in our laboratory for many years with the aim of developing novel metallodrugs. The anticancer potential of complexes bearing Ru2(II,III) metal-metal multiply bonded cores coordinated to NSAIDs has been demonstrated in glioma model cancer. The present proposal for Scientific Initiation research aims to investigate in detail the chemical behavior of the diruthenium-NSAIDs in conditions that might mimic those used in biological assays. The systematic study will contribute to elucidate the phenomenon which may be related to the mode of action of the metallodrugs associated to the biological/pharmacological activity. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCIO HAYASHI; SAMARA R. ALVES; IGUATINÃ M. COSTA; DENISE DE OLIVEIRA SILVA. Self-Assembled Nanoparticles of Diruthenium(II,III)-Ibuprofen Anticancer Metallodrug. Journal of the Brazilian Chemical Society, v. 31, n. 11, p. 2331-2341, . (14/23047-5, 16/23028-6, 14/23481-7)

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