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Analysis of phosphatidylcholine lipid fraction in fat-1 animals in the context of wound healing

Grant number: 16/23298-3
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): July 02, 2017
Effective date (End): October 01, 2017
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Hosana Gomes Rodrigues
Grantee:Thamiris Candreva Robles
Supervisor: Philip Charles Calder
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Research place: University of Southampton, England  
Associated to the scholarship:16/02021-3 - Wound healing in FAT -1 mice: involvement of anti- inflammatory cholinergic pathway, BP.MS


Inflammation is a very important response triggered by tissue injury and its control is crucial for the reestablishment of tissue homeostasis. Nowadays, it is known that the central nervous system (CNS) can regulate the inflammatory response thought the activation of the anti-inflammatory cholinergic pathway. This mechanism involves the liberation of acetylcholine (ACH) that will bind to ±-7 nicotinic receptor in immune cells (such as lymphocytes and macrophages) and trigger the phosphorylation of STAT3 that will induce the production of anti-inflammatory cytokines, such as IL-10, and reduce the release of pro-inflammatory cytokines such as TNF-± and IL-1². We know that fatty acids modulate inflammatory responses through a wide range of actions. For example, they modulate cell membrane composition, affecting the membrane permeability, ligand-receptor interactions, and production of cytokines and regulation of gene expression. However, we don't know if fatty acids can modulate the anti-inflammatory cholinergic pathway. In the present project we will investigate if the fatty acid composition of the cell membrane is related to the anti-inflammatory cholinergic pathway during the wound healing process. For that, we will use transgenic FAT-1 mice that are able to produce É-3 fatty acids, endogenously, from É-6 fatty acids. We will induce a wound in skin and analyze the fatty acid composition of the tissue at different time-points. At the same time, we will measure the synthesis of ACh in the wound tissue samples

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CANDREVA, THAMIRIS; KUHL, CAROLINA M. C.; BURGER, BEATRIZ; DOS ANJOS, MARIAH B. P.; TORSONI, MARCIO A.; CONSONNI, SILVIO R.; CRISMA, AMANDA R.; FISK, HELENA L.; CALDER, PHILIP C.; DE MATO, FELIPE C. P.; et al. Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue. Clinical Science, v. 133, n. 22, p. 2345-2360, . (14/15127-9, 13/06810-4, 16/02021-3, 16/23298-3)

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