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Estimation and evaluation of withdrawal periods for albendazole and its metabolites in fish

Grant number: 16/16593-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2016
Effective date (End): February 09, 2019
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal Investigator:Jonas Augusto Rizzato Paschoal
Grantee:Ana Carolina Vellosa Portela
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:12/18334-0 - Veterinary drug residues in food: multiclass analytical methods employing LC-MS/MS, exposition data and residual depletion study, AP.JP
Associated scholarship(s):17/26290-6 - Analytical method employing QuEChERS and UHPLC-MS/MS for albendazole and its metabolites determination in fish fillet, BE.EP.MS


Currently, aquaculture is the animal food production with the fastest growth in the world. Due to Brazil's extensive freshwater reserves and favorable climates, there are great expectations for the aquaculture sector. Today Brazil is the second largest producer in Latin America and the seventh largest producer of tilapia. However, the practice of intensive aquaculture provides stressful conditions and risk of injury to the animals, which can increase susceptibility to the occurrence of pathogens. Infectious diseases are a major concern because they represent risk to production, affecting productivity. The use of veterinary medicines in productive sector is useful to prevent and treat diseases. However, there are only a few drugs regulated in Brazil that are approved in aquaculture, because of the lack of alternative veterinary medicines and the high cost of drugs available, there is a suspicion that the fish farmers are making use of irregular prescription, or even of banned substances. This practice can lead to possible presence of residues of these substances in animal food, endangering the food safety for consumers. The Albendazole is a broad-spectrum antiparasitic used to treat helminthic parasites in the intestinal tract, widely used in the veterinary field for cattle, sheep and goats, and it has proven to be effective in fish such as tilapia and tambaqui, however it is not regulated for fish farming. The goal of this project is to estimate the grace period of albendazole and its metabolites, by residual depletion test in tambaqui and tilapia (exotic), two very important species of fish that are commercialized in Brazil. From these studies, we will evaluate differences in clearance rates of both species, which have different levels of lipids in the body composition that may interfere with the residual depletion of drugs. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VELLOSA PORTELA, ANA CAROLINA; FERNANDES SILVEIRA, JULIANA GRELL; DAMACENO, MARINA ALVES; BALDO DA SILVA, AGNALDO FERNANDO; DE JESUS, RAPHAEL BARBETTA; PILARSKI, FABIANA; GADAJ, ANNA; MOONEY, MARK H.; RIZZATO PASCHOAL, JONAS AUGUSTO. Food safety evaluation for the use of albendazole in fish: residual depletion profile and withdrawal period estimation. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure, v. 37, n. 4, . (12/18334-0, 16/16593-9, 14/50755-0)
DE FREITAS, LUCAS VICTOR PEREIRA; DA MOTA, CARLOS AUGUSTO ALVARENGA; DAMACENO, MARINA ALVES; SILVEIRA, JULIANA GRELL FERNANDES; PORTELA, ANA CAROLINA VELLOSA; CAMPANHARO, SARAH CHAGAS; DA SILVA, AGNALDO FERNANDO BALDO; ASSANE, INACIO MATEUS; PILARSKI, FABIANA; SASANYA, JAMES JACOB; et al. Residue Depletion Profile and Estimation of Withdrawal Period for Sulfadimethoxine and Ormetoprim in Edible Tissues of Nile Tilapia (Oreochromis sp.) on Medicated Feed. ANIMALS, v. 13, n. 15, p. 13-pg., . (21/03294-1, 19/06159-8, 16/16593-9, 18/05536-0, 21/08152-0, 19/22775-0, 12/18334-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PORTELA, Ana Carolina Vellosa. Estimation and evaluation of withdrawal periods for albendazole and its metabolites in fish. 2019. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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