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Study of AMPA and NMDA receptors at synapses by super resolution microscopy

Grant number: 16/20985-0
Support type:Scholarships abroad - Research
Effective date (Start): August 01, 2017
Effective date (End): July 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Physics - Classical Areas of Phenomenology and Applications
Principal researcher:Andre Alexandre de Thomaz
Grantee:Andre Alexandre de Thomaz
Host: Paul Ronald Selvin
Home Institution: Instituto de Física Gleb Wataghin (IFGW). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: University of Illinois at Urbana-Champaign, United States  


In this project we will study the dynamics of the neurotransmitter receptors upon synaptic plasticity changes. There is a great interest in the study of synaptic plasticity because it is the cellular basis of memory formation. In addition, some neurological disorders are associated with synapse problems like schizophrenia and autism. Techniques that will be used are PALM [Photoactivated Localization Microscopy] and STORM [Stochastic Optical Reconstruction Microscopy], both in live and fixed samples. (AU)

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