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Immunotherapy in experimental asthma by CpG

Grant number: 16/16602-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2016
Effective date (End): February 28, 2019
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Momtchilo Russo
Grantee:Ricardo Wesley Alberca Custódio
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/24694-1 - Immunotherapy of experimental asthma by agonists of toll-like receptors, infection or tolerance, AP.TEM
Associated scholarship(s):18/08699-7 - Characterization of specific T follicular helper cell upon sensitization with Ovalbumin associated with different adjuvants, BE.EP.DR

Abstract

The prevalence and severity of allergies and asthma in particular are increasing worldwide. Currently, asthma is considered a chronic inflammatory pulmonary syndrome in its classic form is associated with the uncontrolled T helper cell 2 (Th2) activities . Murine models have been developed to study the mechanisms of asthma and ovalbumin (OVA) is the most commonly used allergen. In previous work with the OVA model, we show that activation of the immune system by agonists of Toll-like receptors (TLRs) is a potent immune mechanism to reduce allergic reactions. Based on these studies, we postulate that the agonist of TLR 9, CpG containing oligodeoxynucleotides (CPG) may reduce allergic responses directly or indirectly inhibiting the activity of Th2 cells and their action can be enhanced with aggregation to a reagent of liposomal transfection N- [1- (2,3-Dioleoyloxy) propyl] -N, N-methyl N-trimethylammonium sulfate (DOTAP).This project aims to delineate therapeutic applications of CPG using DOTAP in an experimental model of ovalbumin -induced astma and their cellular and molecular mechanisms.

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIROTTI, LUCIANA CRISTINA; ALBERCA CUSTDIO, RICARDO WESLEY; GOMES, ELIANE; RAMMAURO, FLORENCIA; DE ARAUJO, ELISEU FRANK; GARCIA CALICH, VERA LUCIA; RUSSO, MOMTCHILO. CpG-ODN Shapes Alum Adjuvant Activity Signaling via MyD88 and IL-10. FRONTIERS IN IMMUNOLOGY, v. 8, . (16/16602-8, 13/24694-1)
ALBERCA CUSTODIO, RICARDO W.; MIROTTI, LUCIANA; GOMES, ELIANE; NUNES, FERNANDA P. B.; VIEIRA, RAQUEL S.; GRACA, LUIS; ALMEIDA, RAFAEL R.; CAMARA, NIELS O. S.; RUSSO, MOMTCHILO. Dendritic Cells Expressing MyD88 Molecule Are Necessary and Sufficient for CpG-Mediated Inhibition of IgE Production In Vivo. CELLS, v. 8, n. 10, . (15/16728-9, 14/19906-2, 13/24694-1, 16/16602-8)
NUNES, FERNANDA P. B.; ALBERCA-CUSTODIO, RICARDO WESLEY; GOMES, ELIANE; FONSECA, DENISE M.; YOKOYAMA, NICOLE H.; LABRADA, ALEXIS; RUSSO, MOMTCHILO. TLR9 agonist adsorbed to alum adjuvant prevents asthma-like responses induced by Blomia tropicalis mite extract. Journal of Leukocyte Biology, v. 106, n. 3, p. 12-pg., . (15/25364-0, 13/24694-1, 16/16602-8, 15/16728-9)
NUNES, FERNANDA P. B.; ALBERCA-CUSTODIO, RICARDO WESLEY; GOMES, ELIANE; FONSECA, DENISE M.; YOKOYAMA, NICOLE H.; LABRADA, ALEXIS; RUSSO, MOMTCHILO. TLR9 agonist adsorbed to alum adjuvant prevents asthma-like responses induced by Blomia tropicalis mite extract. Journal of Leukocyte Biology, v. 106, n. 3, SI, . (15/16728-9, 15/25364-0, 13/24694-1, 16/16602-8)
ALBERCA, RICARDO W.; GOMES, ELIANE; MORETTI, EDUARDO H.; RUSSO, MOMTCHILO; STEINER, ALEXANDRE A.. Naturally occurring hypothermia promotes survival in severe anaphylaxis. Immunology Letters, v. 237, p. 27-32, . (20/09399-7, 18/08699-7, 13/24694-1, 18/03418-0, 16/16602-8)
ALBERCA-CUSTODIO, RICARDO WESLEY; FAUSTINO, LUCAS D.; GOMES, ELIANE; NUNES, FERNANDA PEIXOTO BARBOSA; DE SIQUEIRA, MIRIAN KRYSTEL; LABRADA, ALEXIS; ALMEIDA, RAFAEL RIBEIRO; CAMARA, NIELS OLSEN SARAIVA; DA FONSECA, DENISE MORAIS; RUSSO, MOMTCHILO. Allergen-Specific Immunotherapy With Liposome Containing CpG-ODN in Murine Model of Asthma Relies on MyD88 Signaling in Dendritic Cells. FRONTIERS IN IMMUNOLOGY, v. 11, . (15/25364-0, 15/16728-9, 14/19906-2, 13/24694-1, 17/05264-7, 16/16602-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CUSTÓDIO, Ricardo Wesley Alberca. Immunotherapy of allergic processes by toll like receptor agonists. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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Filed patent(s) as a result of this research project

COMPOSIÇÃO TERAPÊUTICA E USO DA COMPOSIÇÃO TERAPÊUTICA BR1020180703390 - Universidade de São Paulo (USP) . RICARDO WESLEY ALBERCA CUSTÓDIO / MOMTCHILO RUSSO - October 2018, 02