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Analysis of scaffolds influence of polycaprolactone (PCL) associated with nanohydroxyapatite (nHA), produced by rotary jet spinning in bone repair

Grant number: 16/20820-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2016
Effective date (End): November 30, 2017
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Luana Marotta Reis de Vasconcellos
Grantee:Giovanna Bignoto Minhoto
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil


The bone repair process depends fracture type, mechanical stability and support as regenerative cells. Polycaprolactone (PCL) and a biocompatible synthetic polymer, biodegradable that in association with nanohidroxiapatita (nHAp) may give rise to a bioactive product, not toxic, low cost, with excellent mechanical properties and slow degradation. The rotary jet spinning and a biomaterial production technology, simple, inexpensive and allows fiber production micro / nano. Additionally this technique allows the incorporation of bioactive nanoparticles auch as a nHAp originated biomaterials make composite type (PCL + nHA). The objective this experiment was to evaluate will be production, characterization and bone formation capacity using PCL + nHAp scaffolds produced by rotary jet spinning technique. The scaffolds produced are identified by scanning electron microscopy (SEM). Subsequently, in vivo test it will be used 20 Wistar rats, male, from 90 days old, weighing 300g. The animals are divided randomly in 4 experimental groups (n = 5): G1-control (blood clot); G2 - PCL scaffold; G3 - PCL scaffold with 5% nHAp; G4 - PCL scaffold with 20% nHAp. It will be performed critical defect, with 3mm diameter, the tibia of animals, which will be filled with different scaffold. Control group (G1) will be performed defect and after a suture. All animals will be euthanized 30 days after the surgery. The area of bone repair in the right tibia will be assessed by means of radiographic analysis, histological analysis and histomorphometric. The bone repair area of left tibia wiil be submitted to flexural strength test. The data will be statistically analyzed, initially through the normal trial to the statistical test application suitable. The level of significance adopted will be the conventional value of 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VASCONCELLOS, LUANA M. R.; ELIAS, CONCEICAO DE M. V.; MINHOTO, GIOVANNA B.; ABDALA, JULIA M. A.; ANDRADE, TELMO M.; DE ARAUJO, JULIANI C. R.; GUSMAO, SUZIETE BATISTA SOARES; VIANA, BARTOLOMEU C.; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.. Rotary-jet spun polycaprolactone/nano-hydroxyapatite scaffolds modified by simulated body fluid influenced the flexural mode of the neoformed bone. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 31, n. 8, . (16/20820-0)

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