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Evaluation of the long-term changes in insulin sensitivity of woman that underwent antenatal corticotherapy during pregnancy

Grant number: 16/20488-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Gabriel Forato Anhê
Grantee:Fabíola Sales Furtuoso
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID


Introduction: Corticotherapy during pregnancy demonstrates a relative success in reducing mortality and distress respiratory syndrome incidence in the pre-term newborn. In spite of these immediate benefits, it has been described that babies born to betamethasone-treated mothers are likely to develop insulin resistance in the adolescence. Attempting to evaluate whether this metabolic risk can be extrapolated to the mothers we have developed a pilot study to assess the long-term changes of glucose metabolism in mothers treated with betamethasone during pregnancy (CAAE: 45790715.7.0000.5404). The control groups group (n=31) was consisted by women who did not use betamethasone and underwent uncomplicated gestation and delivery. Mothers that received betamethasone (n=15) presented a trend towards increased insulin levels and HOMA-IR values. The alpha limit of 0.05 was not reached by the comparisons but the power (1-beta) remained around 20%. Aims: To assure whether exists a difference in insulin levels and insulin sensitivity (HOMA-IR) later in life in women who received betamethasone during pregnancy (Case) as compared to women that did not received betamethasone during pregnancy (Control). Subjects and methods: We will prospect deliveries that occurred in CAISM 19 to 22 months before samples collection. The exclusion and the inclusion criteria will be the same for the pilot study (CAAE: 45790715.7.0000.5404).The voluntaries will be invited by phone call and asked to come for a single visit after consenting to participate (TCLE signature). 106 case and 90 controls will be invited. Fasting glucose and insulin levels will be assessed and HOMA-IR will be calculated. Data analysis: Comparisons of the means from Cases and Controls will be performed by student t test or Mann-Whitney depending on parametric distribution (Shapiro). Fasting glucose and insulin and HOMA-IR will be analyzed. Alpha limit for difference will be of 0.05. (AU)

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