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Neuropsychological assessment of children and adolescents with OCD: comparison with healthy controls and impact of treatment

Grant number: 16/04595-7
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2016
Effective date (End): March 31, 2018
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Roseli Gedanke Shavitt
Grantee:Marina de Marco e Souza
Home Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Introduction: The literature on neuropsychological profile of children and adolescents with obsessive-compulsive disorder (OCD) is still quite scarce and inconsistent when it comes to data on the possible cognitive impairment in this population. The aforementioned deterioration relates to fronto-striatal circuitry, especially with regard to executive functions and nonverbal memory. Objectives: To assess possible changes in cognitive functioning of children and adolescents with OCD and associations between neuropsychological measures, clinical data and response to pharmacological and psychotherapeutic treatments. Methods: 86 patients with OCD and 86 healthy controls, aged between 6 and 17 years, will be evaluated by scales and questionnaires to assess psychiatric symptoms and by a battery of neuropsychological tests. All subjects will undergo such assessments at an early time, while patients after being randomized between two possibilities of treatment, cognitive-behavioral group therapy or fluoxetine, will undergo two new assessments: at the 14th and then at the 28th weeks of treatment. Assumptions: 1) patients will present impairments in tasks that assess planning, mental flexibility, inhibitory control and non-verbal episodic memory when compared with healthy controls; 2) the treatments will have a positive influence in the improvement of cognitive functions of patients, especially those that are compromised compared to controls; 3) clinical improvement will correlate positively with improved neuropsychological performance of patients. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERNARDES, ELISA TEIXEIRA; SARAIVA, LEONARDO CARDOSO; DE MARCO E SOUZA, MARINA; QUEIROZ-HOEXTER, MARCELO; CHACON, PRISCILA; REQUENA, GUARACI; MIGUEL, EURIPEDES CONSTANTINO; SHAVITT, ROSELI GEDANKE; POLANCZYK, GUILHERME VANONI; CAPPI, CAROLINA; et al. Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder. BMC Psychiatry, v. 20, n. 1, . (16/05865-8, 16/04595-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Marina de Marco e. Neuropsychological evaluation of children and adolescents with OCD: comparison with healthy controls and post-treatment outcomes. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.