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Effect of acidic and neutral papaya polysaccharides on colon cancer cells

Grant number: 16/19657-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2016
Effective date (End): October 31, 2017
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal researcher:Joao Paulo Fabi
Grantee:Lucas de Freitas Pedrosa
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:12/23970-2 - Biological changes of papaya pectins with possible benefits to human health, AP.JP


Papaya is a fleshy fruit in which pectins are hydrolyzed throughout ripening. Previous studies have suggested these more soluble pectins can induce positive effects in cultured cancer cells. However, the mechanisms that lead to these beneficial effects are still elusive. In this way, the objective of the project is to fractionate the pectins from very ripe papayas in acidic and neutral fractions, to test these fractions in inhibiting the galectin-3 protein and to treat colon cancer cells with the fractions. The viability values will be collected and the inhibitory effects of cells growth will be correlated with the inhibitory effects of the galectin-3. The results will support the discussion about the establishment of a relationship between the chemical structures of papaya pectins and the possible beneficial effects of these substances to the human body. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEDROSA, LUCAS DE FREITAS; LOPES, RODRIGO GUIMARAES; FABI, JOAO PAULO. The acid and neutral fractions of pectins isolated from ripe and overripe papayas differentially affect galectin-3 inhibition and colon cancer cell growth. International Journal of Biological Macromolecules, v. 164, p. 2681-2690, . (16/19657-8, 13/07914-8, 19/11816-8, 12/23970-2)

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