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Structural and Electrochemical Studies of Nanostructures films based on DNA

Grant number: 16/14507-8
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): November 01, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Lauro Tatsuo Kubota
Grantee:Sergio Kogikoski Junior
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/22127-2 - Development of novel materials strategic for integrated analytical devices, AP.TEM
Associated scholarship(s):18/17831-6 - Surface Enhanced Raman Spectroscopy Studies on Self-Assembled DNA Origami Scaffolds, BE.EP.PD


Biosensors uses biomolecules to recognize certain element, and generate a signal that is translated to a biorecognition event, and later quantified. New materials, and principally materials formed by the controlled self-assembly of nucleotides are a promising alternative to the area. Due to the low experimental cost, simplicity, stability and fast response, they attract a lot of attention, however many of its physical-chemical properties are not stablished. In this project, it is proposed the study of the structure properties and its relation with the generated electrochemical signal of DNA based nanostructures. To accomplish it two strategies will be followed, the first uses short DNA strands to promote the self-assembly of three-dimensional crystalline super lattices of gold nanoparticles with controlled orientation. To that, first gold nanoparticles will be modified with thiolated DNA strands, and later will be assembled in films of nanoparticles with body centered cubic unit cell in two distinct orientations (100) and (110) on gold electrodes. The self-assembly process, and the electrochemical properties will be studied in function of the number of layers, nanoparticles diameter and orientation of the crystallographic plane, in that way we expect to achieve controlled electrochemical response by controlling the structure of the film. The second proposal is the use of DNA nanotetrahedrons, this kind of nanostructure presents great stability and easy preparation procedures, more than that it forms thin films with excellent control of surface coverage. It is proposed here the study the electrode surface modification process and study the electrochemical properties of it. With the obtained results, it is proposed the use of the novel interfaces to the development of application in integrated bio-sensors with enhanced sensibility, stability, linear range and lower detection limits levels.

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KOGIKOSKI, JR., SERGIO; KHANRA, SOMA; ALVES, WENDEL A.; GUHA, SUCHISMITA. SERS active self-assembled diphenylalanine micro/nanostructures: A combined experimental and theoretical investigation. Journal of Chemical Physics, v. 147, n. 8, . (16/14507-8, 12/01933-8, 15/24018-1)
PASCHOALINO, WALDEMIR J.; KOGIKOSKI, JR., SERGIO; BARRAGAN, JOSE T. C.; GIAROLA, JULIANA F.; CANTELLI, LORY; RABELO, THAIS M.; PESSANHA, TATIANA M.; KUBOTA, LAURO T.. Emerging Considerations for the Future Development of Electrochemical Paper-Based Analytical Devices. CHEMELECTROCHEM, v. 6, n. 1, SI, p. 10-30, . (17/05213-3, 16/08166-3, 16/14507-8, 13/22127-2, 14/50867-3)
KOGIKOSKI, JR., SERGIO; PASCHOALINO, WALDEMIR J.; KUBOTA, LAURO T.. Supramolecular DNA origami nanostructures for use in bioanalytical applications. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 108, p. 88-97, . (16/14507-8, 14/50867-3, 13/22127-2, 17/05213-3)
KOGIKOSKI, JR., SERGIO; PASCHOALINO, WALDEMIR J.; CANTELLI, LORY; SILVA, WILGNER; KUBOTA, LAURO T.. Electrochemical sensing based on DNA nanotechnology. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 118, p. 597-605, . (14/50867-3, 16/14507-8, 17/05213-3, 13/22127-2)
KOGIKOSKI, JR., SERGIO; KUBOTA, LAURO T.. Electrochemical behavior of self-assembled DNA-gold nanoparticle lattice films. Electrochemistry Communications, v. 90, p. 51-55, . (16/14507-8, 14/50867-3, 13/22127-2)
KOGIKOSKI JR, SERGIO; DUTTA, ANUSHREE; BALD, ILKO. patial Separation of Plasmonic Hot-Electron Generation and a Hydrodehalogenation Reaction Center Using a DNA Wir. ACS NANO, v. 15, n. 12, p. 20562-20573, . (18/17831-6, 16/14507-8)
BARRAGAN, JOSE T. C.; KOGIKOSKI, JR., SERGIO; DA SILVA, EVERSON T. S. G.; KUBOTA, LAURO T.. Insight into the Electro-Oxidation Mechanism of Glucose and Other Carbohydrates by CuO-Based Electrodes. Analytical Chemistry, v. 90, n. 5, p. 3357-3365, . (16/14507-8, 14/50867-3, 13/22127-2, 15/13810-6)
PESSANHA, TATIANA M.; PASCHOALINO, WALDEMIR J.; DEROCO, PATRICIA B.; KOGIKOSKI, SERGIO; DE MORAES, ANA C. M.; CASTRO SILVA, CECILIA CARVALHO; KUBOTA, LAURO T.. Interfacial Capacitance of Graphene Oxide Films Electrodes: Fundamental Studies on Electrolytes Interface Aiming (Bio)Sensing Applications. Electroanalysis, . (17/05213-3, 13/22127-2, 14/50867-3, 16/14507-8)
KOGIKOSKI JR, SERGIO; KUBOTA, LAURO T.. Electron transfer in superlattice films based on self-assembled DNA-Gold nanoparticle. Electrochimica Acta, v. 318, p. 931-936, . (14/50867-3, 18/17831-6, 16/14507-8, 13/22127-2)

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