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Validation of differential expression of microRNAs in exosomes from peripheral blood from pregnant women with preterm labor and preterm premature rupture of membranes

Grant number: 16/13616-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2016
Effective date (End): September 30, 2018
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Bruna Ribeiro de Andrade Ramos
Grantee:Jéssica Maria Diehl
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Preterm Labor (PTL) and Preterm Premature Rupture of Membranes (PPROM) are responsible for severe perinatal morbidity and neonatal mortality worldwide. MicroRNAs (miRNAs) can affect gestational outcome and are potential biomarkers for these complications. Exosomes act in cell communication, contain miRNAs and increase their stability. Objective: To compare the expression, in exosomes from peripheral blood, of the miRNAs miR-143-3p, miR-145-5p and miR-199a-5p between women with term pregnancies and PTL or PPROM. Patients and methods: Case-control study with women that underwent PTL, PPROM, term pregnancy with and without labor and non-pregnant women seen at Botucatu Medical School. Exosomes will be isolated from plasma and expression of miRNAs will be performed by Real Time PCR. Statistical analysis will be performed according to the results obtained and a p-value of 5% will be adopted.

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