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Antimicrobial surfaces bionspired by the acid mantle based on Keggin-type heteropoly acids

Grant number: 16/16098-8
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): December 01, 2016
Effective date (End): October 21, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Ubirajara Pereira Rodrigues Filho
Grantee:Roger Honorato Piva
Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

Colonization by pathogenic microorganisms on inanimate surfaces in hospitals and medical supplies is one of the major causes of healthcare-associated infections (HCAI, also known as nosocomial). As an aggravating factor, cases of HCAI due to resistant microorganisms are increasing rapidly, whereas deaths by this HCAI is becoming a global threat. Today, prevention is a key methodology capable of minimize the HCAI crisis due the antimicrobial resistance. An emerging strategy that has received much attention is the surface functionalization by antimicrobial inorganic materials to prevent colonization and subsequent outbreaks of pathogenic microorganisms. The purpose of this project is to assess the ability of insoluble Keggin-type heteropoly acids as a new family of inorganic antimicrobials regulated via hydroxonium ions (H3O+). It is hypothesized that Keggin-type heteropoly acids can improve the recent technology of antimicrobial surfaces bioinspired by the acid mantle of human skin. First, experiments will be conducted to elucidate the antimicrobial mechanism of action of heteropoly acids. This step is crucial to validate the hypothesis of these compounds as an innovative antimicrobial with broad spectrum of action against pathogenic microorganisms, no regulation by release of heavy metal ions, and active under dark conditions. Later, heteropoly acids-based antimicrobial films will be prepared by layer-by-layer (LbL) fabrication technique. The success of the proposal will introduce new inorganic antimicrobials for the functionalization of surfaces and hospital products against colonization by pathogenic microorganisms.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PIVA, ROGER HONORATO; ROCHA, MARINA CAMPOS; PIVA, DIOGENES HONORATO; KLEGUES MONTEDO, OSCAR RUBEM; IMASATO, HIDETAKE; MALAVAZI, IRAN; RODRIGUES-FILHO, UBIRAJARA PEREIRA. Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent. JOURNAL OF MATERIALS CHEMISTRY B, v. 6, n. 1, p. 143-152, . (15/17541-0, 16/16098-8)
PIVA, ROGER H.; ROCHA, MARINA C.; PIVA, DIOGENES H.; IMASATO, HIDETAKE; MALAVAZI, IRAN; RODRIGUES-FILHO, UBIRAJARA P.. Acidic Dressing Based on Agarose/Cs2.5H0.5PW12O40 Nanocomposite for Infection Control in Wound Care. ACS APPLIED MATERIALS & INTERFACES, v. 10, n. 37, p. 30963-30972, . (15/17541-0, 16/16098-8, 18/00315-5, 17/19694-3)

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Filed patent(s) as a result of this research project

NANOCOMPÓSITO CONTENDO NANOPARTÍCULAS DE FOSFOTUNGSTATO ÁCIDO DE CÉSIO E USO DAS NANOPARTÍCULAS COMO AGENTE ANTIMICROBIANO DE AMPLO ESPECTRO DE AÇÃO BR102019017563-0 - Universidade de São Paulo (USP) . Ubirajara Pereira Rodrigues Filho / IRAN MALAVAZI / HIDETAKE IMASATO / MARINA CAMPOS ROCHA / ROGER HONORATO PIVA - August 2019, 22