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Serotonin epithelial synthesis impacts on the development of colon carcinogenesis

Grant number: 16/12619-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): October 01, 2016
Effective date (End): October 22, 2017
Field of knowledge:Biological Sciences - Genetics - Mutagenesis
Principal Investigator:Vinicius Kannen Cardoso
Grantee:Bianca Gasparotto
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/06428-5 - Differentiating the effects of epithelial from the neural serotoninergic signalling during inflammation-related colon cancer, AP.JP

Abstract

Intestinal neuroendocrine epithelial cells synthesize the highest body levels of serotonin (5-HT). Although 5-HT has been thought to promote the development of colon carcinogenesis, how it promotes colon cancer remains unknown. We will investigate the effects of 5-HT on colon carcinogenesis in either carcinogen-exposed or -unexposed (azoxymethane; AOM) wildtype (+/+) and knockout mice (-/-) for the enzyme tryptophan hydroxylase 1 (Tph1+/+; Tph1-/-). Current project has a work plan for one-and-half years. Future findings will provide a novel understanding on the role of the serotonergic system in colon carcinogenesis. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SAKITA, JULIANA Y.; BADER, MICHAEL; SANTOS, EMERSON S.; GARCIA, SERGIO B.; MINTO, STEFANIA B.; ALENINA, NATALIA; BRUNALDI, MARIANGELA O.; CARVALHO, MILENE C.; VIDOTTO, THIAGO; GASPAROTTO, BIANCA; et al. Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis. JOURNAL OF PATHOLOGY, v. 249, n. 1, p. 102-113, . (17/01260-7, 14/06428-5, 15/01723-1, 16/12619-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GASPAROTTO, Bianca. Effects of serotonin epithelial synthesis on the development of colon carcinogenesis. 2017. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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