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Histopathological correlates of magnetic resonance imaging in patients with drug-resistant epilepsies

Grant number: 15/20840-9
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2016
Effective date (End): August 19, 2019
Field of knowledge:Health Sciences - Medicine - Medical Radiology
Principal Investigator:João Pereira Leite
Grantee:José Eduardo Peixoto Santos
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):17/03739-8 - Histopathological correlates of magnetic resonance imaging in patients with drug-resistant epilepsies, BE.EP.PD

Abstract

Magnetic resonance imaging (MRI) is an important non-invasive tool for the evaluation of several conditions. In drug-resistant epilepsies, surgical outcome depends largely on complete removal of the epileptogenic region, making MRI crucial for surgical planning. Hippocampal sclerosis and cortical dysplasia are the most common pathological surgical findings in these drug-resistant patients, and are detected in MRI as increased T2 signal, reduced magnetization transfer and increased mean water diffusion. However, most cortical dysplasias remain undetected by the most modern MRI protocols, and data from our previous studies indicate that even hippocampal sclerosis may not be detected always. Consequently, a significant percentage of patients fail to achieve postsurgical seizure control. Thereby, it is important to optimize MRI to detect more subtle pathological changes, as well as to define the pathological substrates of the MR signals. Our aim is to identify, by proteomics, the histologic substrates of the different MRI protocols, and to improve the detection of cortical dysplasias by quantitative MRI. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUENO-JUNIOR, LEZIO S.; PEIXOTO-SANTOS, JOSE E.; RUGGIERO, RAFAEL N.; AVILA, MILTON A. V.; MARQUES, DANILO B.; LOPES-AGUIAR, CLEITON; LEITE, JOAO P.. Interaction between hippocampal-prefrontal plasticity and thalamic-prefrontal activity. SCIENTIFIC REPORTS, v. 8, . (15/20840-9, 12/23918-0, 12/06123-4, 14/18211-0, 16/17882-4)
LOPES BORN, JOAO PAULO; MATOS, HELOISA DE CARVALHO; DE ARAUJO, MYKAELLA ANDRADE; CASTRO, OLAGIDE WAGNER; DUZZIONI, MARCELO; PEIXOTO-SANTOS, JOSE EDUARDO; LEITE, JOAO PEREIRA; GARCIA-CAIRASCO, NORBERTO; PACO-LARSON, MARIA LUISA; GOES GITAI, DANIEL LEITE. Using Postmortem hippocampi tissue can interfere with differential gene expression analysis of the epileptogenic process. PLoS One, v. 12, n. 8, . (16/17882-4, 15/20840-9)
DO VAL-DA SILVA, RAQUEL A.; PEIXOTO-SANTOS, JOSE E.; KANDRATAVICIUS, LUDMYLA; DE ROSS, JANA B.; ESTEVES, INGRID; DE MARTINIS, BRUNO S.; ALVES, MARCELA N. R.; SCANDIUZZI, RENATA C.; HALLAK, JAIME E. C.; ZUARDI, ANTONIO W.; et al. Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy. FRONTIERS IN PHARMACOLOGY, v. 8, . (16/17882-4, 15/20840-9)
PEIXOTO-SANTOS, JOSE EDUARDO; VELASCO, TONICARLO R.; CARLOTTI, CARLOS GILBERTO; ASSIRATI, JOAO ALBERTO; DE SOUZA E REZENDE, GUSTAVO HENRIQUE; KOBOW, KATJA; CORAS, ROLAND; BLUMCKE, INGMAR; GARRIDO SALMON, CARLOS ERNESTO; DOS SANTOS, ANTONIO CARLOS; et al. Histological correlates of hippocampal magnetization transfer images in drug-resistant temporal lobe epilepsy patients. NEUROIMAGE-CLINICAL, v. 28, . (16/17882-4, 15/20840-9)
PEIXOTO-SANTOS, JOSE EDUARDO; DRUMOND DE CARVALHO, LUCIANA ESTEFANI; KANDRATAVICIUS, LUDMYLA; BESERRA DINIZ, PAULA REJANE; SCANDIUZZI, RENATA CALDO; CORAS, ROLAND; BLUEMCKE, INGMAR; ASSIRATI, JOAO ALBERTO; CARLOTTI, CARLOS GILBERTO; MARCONATO SIMOES MATIAS, CAIO CESAR; et al. Manual Hippocampal Subfield Segmentation Using High-Field MRI: Impact of Different Subfields in Hippocampal Volume Loss of Temporal Lobe Epilepsy Patients. FRONTIERS IN NEUROLOGY, v. 9, . (15/20840-9, 16/17882-4, 17/03739-8)
PEIXOTO-SANTOS, JOSE EDUARDO; KANDRATAVICIUS, LUDMYLA; VELASCO, TONICARLO RODRIGUES; ASSIRATI, JOAO ALBERTO; CARLOTTI, CARLOS GILBERTO; SCANDIUZZI, RENATA CALDO; GARRIDO SALMON, CARLOS ERNESTO; DOS SANTOS, ANTONIO CARLOS; LEITE, JOAO PEREIRA. Individual hippocampal subfield assessment indicates that matrix macromolecules and gliosis are key elements for the increased T2 relaxation time seen in temporal lobe epilepsy. Epilepsia, v. 58, n. 1, p. 149-159, . (15/20840-9, 16/17882-4)
ROSSIGNOLI, MATHEUS TEIXEIRA; LOPES-AGUIAR, CLEITON; RUGGIERO, RAFAEL NAIME; DO VAL DA SILVA, RAQUEL ARAUJO; BUENO-JUNIOR, LEZIO SOARES; KANDRATAVICIUS, LUDMYLA; PEIXOTO-SANTOS, JOSE EDUARDO; CRIPPA, JOSE ALEXANDRE; CECILIO HALLAK, JAIME EDUARDO; ZUARDI, ANTONIO WALDO; et al. SELECTIVE POST-TRAINING TIME WINDOW FOR MEMORY CONSOLIDATION INTERFERENCE OF CANNABIDIOL INTO THE PREFRONTAL CORTEX: REDUCED DOPAMINERGIC MODULATION AND IMMEDIATE GENE EXPRESSION IN LIMBIC CIRCUITS. Neuroscience, v. 350, p. 85-93, . (16/17882-4, 12/23918-0, 14/09772-9, 15/20840-9)
LEITE, JOAO PEREIRA; PEIXOTO-SANTOS, JOSE EDUARDO. Glia and extracellular matrix molecules: What are their importance for the electrographic and MRI changes in the epileptogenic zone?. Epilepsy & Behavior, v. 121, n. B, . (16/17882-4, 15/20840-9)

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