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Immunomodulation of acute experimental hepatitis by the Aedes aegypti mosquito saliva

Grant number: 16/11523-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2016
Effective date (End): May 31, 2018
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:Anderson de Sá Nunes
Grantee:Josiane Betim de Assis
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Autoimmune hepatitis is a disease characterized by a destruction of hepatocytes promoted by the immune system, causing inflammation and progressive loss of liver function. If untreated, the disease progresses, compromising the liver and generating extrahepatic damage. Although therapy with corticosteroids is able to control the symptoms, the treatment is often insufficient for complete remission. Knowing the biological activities of the compounds present in the saliva of hematophagous insects, and based on previous results from our group, we believe that the salivary components of Aedes aegypti mosquito can be employed to treat autoimmune diseases due to their capacity of influencing/modulating the immune responses. In order to investigate this possibility, a well-established model for the study of autoimmune hepatitis, acute experimental hepatitis (HEA) induced by concanavalin A (Con A), will be employed. In this model, a disease mediated by infiltration of CD4+ T lymphocytes, macrophages and NKT cells in the liver is induced, with the systemic production of a number of inflammatory cytokines. Preliminary data from our laboratory shows that the exposure of animals to A. aegypti mosquito bites prevents increased levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), enzymes related to the liver damage induced by Con A inoculation, suggesting an improvement of the clinical signs of the disease. The objective of this project is to evaluate the therapeutic potential of A. aegypti saliva in the HEA model induced by Con A and characterize the immune phenotype associated with this effect.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ASSIS, JOSIANE B.; COGLIATI, BRUNO; ESTEVES, ELIANE; CAPURRO, MARGARETH L.; FONSECA, DENISE M.; SA-NUNES, ANDERSON. Aedes aegypti mosquito saliva ameliorates acetaminophen-induced liver injury in mice. PLoS One, v. 16, n. 2, . (16/11523-2, 09/09892-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ASSIS, Josiane Betim de. Immunomodulation of acute experimental hepatitis by the Aedes aegypti mosquito saliva. 2018. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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