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Colloidal stability and protein corona: fundamental aspects for maintaining silica nanoparticle properties in biologial media

Grant number: 16/16905-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): September 01, 2016
Effective date (End): January 31, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Mateus Borba Cardoso
Grantee:Gabriela Borba Mondo
Home Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovações (Brasil). Campinas , SP, Brazil
Associated research grant:15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles, AP.TEM
Associated scholarship(s):19/26789-6 - Zwitterionic peptide-conjugated silica nanoparticles for improved proprieties towards nanomedical applications, BE.EP.DD


Nanoparticles are promising plataforms for applications in biological systems due to their size and functionalization possibilities. However, loss of colloidal stability and formation of protein corona has hindered clinical translation of nanoparticles. This change in colloidal stability and the formation of protein corona influence the final characteristics of the nanoparticles and their physical-chemical properties. creating a new biological identity for the nanomaterial. The goal here is to study the colloidal stability and the protein corona formation over silica nanoparticles of approximately 100 nm with different surface modifications. Particularly, evaluation of silica nanoparticles with a zwitterionic silane will be studied, to elucidate aspects that grant colloidal stability to these nanoparticles when in biological fluids. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA CRUZ SCHNEID, ANDRESSA; ALBUQUERQUE, LINDOMAR JOSE CALUMBY; MONDO, GABRIELA BORBA; CEOLIN, MARCELO; PICCO, AGUSTIN SILVIO; CARDOSO, MATEUS BORBA. Colloidal stability and degradability of silica nanoparticles in biological fluids: a review. Journal of Sol-Gel Science and Technology, . (16/16905-0, 15/25406-5, 18/00763-8, 19/24894-7)
LOIOLA, LIVIA M. D.; BATISTA, MARINA; CAPELETTI, LARISSA B.; MONDO, GABRIELA B.; ROSA, RHUBIA S. M.; MARQUES, RAFAEL E.; BAJGELMAN, MARCIO C.; CARDOSO, MATEUS B.. Shielding and stealth effects of zwitterion moieties in double-functionalized silica nanoparticles. Journal of Colloid and Interface Science, v. 553, p. 540-548, . (17/09203-2, 15/25406-5, 16/21598-0, 17/01167-7, 17/06692-2, 16/16905-0)
BOUCHMELLA, KARIM; CAMPANARO, FELIPE DAVI; MONDO, GABRIELA BORBA; SANTOS, MURILO IZIDORO; FRANCO, CAIO HADDAD; MORAES, CAROLINA BORSOI; BIOLLEY, CHRISTINE; MEHDI, AHMAD; CARDOSO, MATEUS BORBA. Tetracycline@silverions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration. Nanomedicine, v. 13, n. 14, p. 1731-1751, . (16/16905-0, 15/25406-5, 14/22322-2)
PICCO, AGUSTIN S.; FERREIRA, LARISSA F.; LIBERATO, MICHELLE S.; MONDO, GABRIELA B.; CARDOSO, MATEUS B.. Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications. Nanomedicine, v. 13, n. 2, p. 179-190, . (14/21910-8, 16/16905-0, 15/25406-5, 14/22322-2, 17/02145-7)

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