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INFLAMMATION IN DOGS WITH BRAIN Visceral Leishmaniasis : Molecular Research of the Adaptive Immune Response

Grant number: 16/14828-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2016
Effective date (End): August 31, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Gisele Fabrino Machado
Grantee:Livia Castanhas Bregano
Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Visceral leishmaniasis (VL) is a canine disease with variable clinical manifestation and complex pathogenesis.Dogs may have subclinical to widespread alterations and severe systemic disorders. Because of brain inflammatory changes, it is now known that chronically infected dogs may have significant neurological deficits. Despite the clinical importance of this disorder, there are few reports that characterize neurological injuries in LV. Recent studies showed the presence of brain inflammation by lymphocyte infiltration of observation T, glial cell activation, degenerative changes of neurons, meningitis, choroiditis, and the presence of enzymes such as matrix metalloproteinases. Continuing the previous projects, this study seek to evaluate, through the gene expression, the complex profile subsets of CD4 + effector cells, and their activation related to the adaptive response in brains of dogs with LV. Added to this, the comparison of this profile will be held the expression of the same markers in the spleen, and the correlation between the profile and histopathology of brain lesions, thus seeking to contribute to better understanding of the mechanisms involved in the pathological findings in the brain of these animals.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BREGANO, Livia Castanhas. Genes of the innate and adaptive imune response differentially expressed in dog brains with Visceral Leishmaniasis. 2018. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.

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