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Grant number: 16/05047-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2016
Effective date (End): December 31, 2018
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Stela Márcia Mattiello
Grantee:Aline Castilho de Almeida
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:13/00798-2 - The extracellular matrix in aging, exercise and in the tumor microenvironment, AP.TEM
Associated scholarship(s):16/22884-6 - Changes in strength and thigh composition in older adults with knee osteoarthritis, BE.EP.DR


Introduction: The increase in intermuscular adipose tissue (IMAT) can contribute to muscle weakness and consequently on progression of knee OA. The prescription of exercise protocols has been used as a treatment strategy to minimize some of the bouts. Circuit training (CT) involves the combination of strength training and aerobic in the same session and has shown benefits in body composition and physical function. But the literature is unclear with respect to the influences of CT in the concentration of IMAT in the population with knee OA. Objective: To compare the influence of a 14-week CT protocol with a strength training protocol (ST) and an educational protocol on body composition and thigh IMAT concentration as well as cartilage degradation indicators and systemic inflammation and its impact on quality of life in patients with knee OA. Method: This study presents a clinical trial randomized controlled design. Will be selected 60 participants diagnosed with knee OA grades II and III, aged 40 and 65 years and BMI <30 kg / m2 will be randomly divided into three groups: participants submitted to circuit training (GTC), submitted to strength training (GTF) and not subjected to training, which will hold the educational protocol (GPE), which consist of weekly visits with guidance on healthy lifestyle. Participants in the GTC group will undergo periodization training protocols 14 weeks load progression, with sessions lasting 15 minutes in the first weeks and will arrive 35 minutes in final weeks, and added 10 minutes between heating and cooling down. The GTF will be subjected to exercise. strengthening also for 14 weeks, using training volume composed of sets and repetitions, without following the model of progression of CT charges. The CT will be performed three times a week, and ST will be performed twice a week. All participants will conduct pre and post CT variables: IMAT thigh (CT); body composition (bone densitometry - DXA), inflammatory biomarker concentrations: IL-1², IL-6, IL-10, TNF-±, leptin and adiponectin and joint degradation biomarkers (uCTX-II and SCOMP), performance tests functional (six-minute walk, sit and lift up and down stairs), muscle strength (maximum voluntary isometric contraction - CIVM), WOMAC questionnaires, and KOOS scale catastrophizing pain. During the training protocol, uCTX-II variables, sCOMP and CIVM will also be evaluated. To compare the groups the ANOVA one-way will be applied. When found significant main effects, the Bonferroni test is used to identify the statistically significant differences. To compare the collections times (pre, during and post training) for uCTX-II variables, Scomp and CIVM will be held repeated measures ANOVA with post hoc Bonferroni, and the WOMAC variables, KOOS, DXA, CT , functional testing and inflammatory cytokines (pre and post CT) will be held the paired t test. a significance level of 5% (p d 0.05) will be adopted.Keywords: intermuscular fat, circuit workouts, adipokines, quadriceps, inflammation, CT scan, physical therapy, rehabilitation

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEDROSO, MARIA GABRIELA; DE ALMEIDA, ALINE CASTILHO; AILY, JESSICA BIANCA; DE NORONHA, MARCOS; MATTIELLO, STELA MARCIA. Fatty infiltration in the thigh muscles in knee osteoarthritis: a systematic review and meta-analysis. RHEUMATOLOGY INTERNATIONAL, v. 39, n. 4, p. 627-635, . (16/05047-3, 15/19232-4)
DE ALMEIDA, ALINE CASTILHO; AILY, JESSICA BIANCA; PEDROSO, MARIA GABRIELA; GONCALVES, GLAUCIA HELENA; PASTRE, CARLOS MARCELO; MATTIELLO, STELA MARCIA. Reductions of cardiovascular and metabolic risk factors after a 14-week periodized training model in patients with knee osteoarthritis: a randomized controlled trial. CLINICAL RHEUMATOLOGY, v. 40, n. 1, . (13/00798-2, 16/05047-3)
DE ALMEIDA, ALINE CASTILHO; AILY, JESSICA BIANCA; PEDROSO, MARIA GABRIELA; GONCALVES, GLAUCIA HELENA; FELINTO, JONAS DE CARVALHO; FERRARI, RICARDO JOSE; PASTRE, CARLOS MARCELO; MATTIELLO, STELA MARCIA. A periodized training attenuates thigh intermuscular fat and improves muscle quality in patients with knee osteoarthritis: results from a randomized controlled trial. CLINICAL RHEUMATOLOGY, v. 39, n. 4, p. 1265-1275, . (16/05047-3, 13/00798-2)
DE ALMEIDA, ALINE CASTILHO; PEDROSO, MARIA GABRIELA; AILY, JESSICA BIANCA; GONCALVES, GLAUCIA HELENA; PASTRE, CARLOS MARCELO; MATTIELLO, STELA MARCIA. Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: protocol for a randomized controlled trial. BMC MUSCULOSKELETAL DISORDERS, v. 19, . (16/05047-3, 13/00798-2)

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