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Simultaneous identification and quantification of cytochrome-P450 pathway (CYP450)-derived eicosanoids using high performance liquid chromatography coupled to sequential mass spectrometry (HPLC-MS/MS)

Grant number: 16/16788-4
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): September 01, 2016
Effective date (End): October 29, 2018
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Lúcia Helena Faccioli
Grantee:Ana Paula Ferranti Peti
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/07125-6 - New functional aspects of eicosanoids, AP.TEM


In recent years new functions of EICs have been described, but much still needs to be researched on these lipids. This Thematic project aims to explore new aspects of EICs in six distinct and innovative subprojects. We will investigate the production and functions of EICs in five of them: (i) Investigation of the involvement of eicosanoids in chronic unpredictable stress-induced depression; (ii) Profile of macrophages, eicosanoid metabolism and tumor-associated activity; (iii) Relationship between activation of the inflammasome, production of lipid mediators, lung inflammation and death induced by scorpion venom; (iv) Involvement of aryl hydrocarbon receptor in the polarization of Treg, Th17 and Th22 cells and eicosanoids production in Histoplasma capsulatum infection; (v) Evaluation of the involvement of 5-lipoxygenase metabolites in Achromobacter xylosoxidans pulmonary infection. The last, (vi) Eicosanoid lipidomics from leukocytes of healthy individuals, aims to determine values of EICs production by leukocytes of healthy subjects for future comparison of production by patient's cells. This Thematic will be carried out by a multidisciplinary, multi-institutional and transnational team, with confirmed competency in different areas of the subproject, linked by a common topic, which is the study of new functional aspects of EICs. Moreover, we intend to establish a core reference for identification of EICs, by mass spectrometry. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SORGI, CARLOS ARTERIO; FERRANTI PETI, ANA PAULA; PETTA, TANIA; GALVAO MEIRELLES, ALYNE FAVERO; FONTANARI, CAROLINE; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. SCIENTIFIC DATA, v. 5, . (14/07125-6, 16/16788-4, 15/00658-1)
ACUNHA, TANIZE; NARDINI, VIVIANI; FERRANTI PETI, ANA PAULA; BORGES PRADO, MORGANA KELLY; BERALDO MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. Targeted analysis of eicosanoids derived from cytochrome P450 pathway by high-resolution multiple-reaction monitoring mass spectrometry. Journal of Mass Spectrometry, v. 56, n. 7, . (16/16788-4, 15/00658-1, 14/07125-6, 18/25704-4)
FERRANTI PETI, ANA PAULA; LOCACHEVIC, GISELE APARECIDA; BORGES PRADO, MORGANA KELLY; BERALDO DE MORAES, LUIZ ALBERTO; FACCIOLI, LUCIA HELENA. High-resolution multiple reaction monitoring method for quantification of steroidal hormones in plasma. Journal of Mass Spectrometry, v. 53, n. 5, p. 423-431, . (14/07125-6, 16/16788-4, 15/00658-1)

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