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Vitamin D concentrations in women and newborns: relation to birth weight and gestational age

Grant number: 16/07882-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2017
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Fabíola Isabel Suano de Souza
Grantee:Fernanda Ramires Cafeo
Host Institution: Faculdade de Medicina do ABC (FMABC). Organização Social de Saúde. Fundação do ABC. Santo André , SP, Brazil

Abstract

Vitamin D (VITD) is recognized as a pro-hormone involved in bone metabolism and functioning of the immune, respiratory, endocrine and cardiovascular systems. Pregnant women and infants are high risk groups for VITD deficiency. recent systematic review described the 25 concentrations (OH) VitD3 on 5 continents and found it to be compatible with disabilities in 46-87% of women and 30-73% of newborns. The World Health Organization does not recommend routinely supplementation VITD in pregnant women. While recognizing the high prevalence of this deficiency the available studies found no clear benefits of supplementation to the mother and newborn, in addition, few assessed possible adverse effects. Objective: To describe, at delivery, concentrations of 25 (OH) VitD3 maternal and umbilical cord of newborns at term (RNT) and compare with pre-term newborns (PTN). In addition to relate the concentration of 25 (OH) VitD3 the umbilical cord with the mother. Method: This cross-sectional study will be included, from 23 September to 22 December 2016, 30 pairs - mothers and their infants to term (RNT) and appropriate birth weight (AIG) - Municipal Hospital Universitario de São Bernardo do Campo (HMU-SBC). Each pair will be paired with someone whose birth was premature (<32 weeks) being included by another research project that is being developed at the same hospital since February 2016. Expected results: expected to find high prevalence of deficiency VITD in the study population, mothers and newborns, especially among preterm infants. Umbilical cord VITD concentrations should be correlated with maternal.

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