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Deposition and functionalization of TiO2 thin films surface

Grant number: 16/11183-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2016
Effective date (End): December 31, 2017
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Paulo Noronha Lisboa Filho
Grantee:Leonardo Francisco Gonçalves Dias
Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
Associated research grant:13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID


This proposal is part of a multidisciplinary approach, inserted in the new area of nanobiotechnology, which should revolutionize the diagnosis and treatment of various diseases and conditions. The nanostructured titanium dioxide (TiO2) has been employed as surface modifiers in medical implants, promoting improved resistance biocorrosion material and increased bioactivity of oxides, with promising results in the interaction with living tissue. Despite the biocompatibility of this oxide to be recognized, there are still many aspects of adhesion mechanisms between the proteins and the surface of the material.Chemically the surface of these oxides is particularly terminated by OH groups which can be readily functionalized. Such chemical functionalization or simply a physical modification of the material surface, can improve the interaction of the oxide with the biological environment.This project proposes to synthesize TiO2 thin films on metallic titanium substrates using spin coating technique and study different functionalization strategies surfaces. The aim is also to evaluate the physicochemical and thermodynamic parameters in order to analyze the best interaction and adsorption of protein to metal surface, since different biomedical applications require different properties of protein-oxide interaction. Different strategies and functionalization of adsorption will be studied and tested in vitro biological systems.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRONZE-UHLE, ERIKA S.; DIAS, LEONARDO F. G.; TRINO, LUCIANA D.; MATOS, ADRIANA A.; DE OLIVEIRA, RODRIGO C.; LISBOA-FILHO, PAULO N.. Physicochemical characterization of albumin immobilized on different TiO2 surfaces for use in implant materials. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 564, p. 39-50, . (14/01713-3, 14/20471-0, 16/11183-7, 17/15035-5)
BRONZE-UHLE, ERIKA S.; DIAS, LEONARDO F. G.; TRINO, LUCIANA D.; MATOS, ADRIANA A.; DE OLIVEIRA, RODRIGO C.; LISBOA-FILHO, PAULO N.. Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application. SURFACE & COATINGS TECHNOLOGY, v. 357, p. 36-47, . (14/01713-3, 14/20471-0, 16/11183-7, 17/15035-5)

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