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Plasmodium vivax genomic analysis: identification of relapses and association with pregnancy adverse outcome in women from the Brazilian Amazon

Grant number: 16/13465-0
Support Opportunities:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): September 30, 2016
Effective date (End): January 29, 2017
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Cláudio Romero Farias Marinho
Grantee:Jamille Gregório Dombrowski
Supervisor: Susana Gomes Campino
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: London School of Hygiene and Tropical Medicine, England  
Associated to the scholarship:12/04755-3 - Association of gestational malaria with intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon, BP.DD


Malaria in pregnancy is a serious public health problem and is characterized by the presence of Plasmodium spp. in the peripheral blood or the placenta, impacting on maternal and foetal health. Although P. vivax burden in pregnancy is less described than P. falciparum, recent studies indicate that both species represent a threaten to mother and foetus. Nevertheless, several hypotheses have been raised to explain the differential pregnancy outcomes upon vivax infection, from the host to the parasite side. One of the hypothesis is related to Plasmodium genetic structure that has been implicated in the severity of the disease. Actually, whereas it is clear that placental parasites present a distinct phenotype from those in peripheral circulation, it is not yet known if they differ genetically. In fact, preliminary analysis of a prospective follow-up cohort with pregnant women conducted by us in the Amazon region revealed a clear distinct profile in placental pathology and the occurrence of a large number of infection recurrences with a pattern similar to vivax relapses, during pregnancy upon vivax infection. These provided the rationale to develop a project to evaluate the genetic structure and diversity of P. vivax among pregnant women from the Brazilian Amazon. Thus, we propose to study the P. vivax genomics on samples isolated from pregnant women, through whole-genome Illumina paired-end sequencing on the MiSeq Analyser. This will allow to identify vivax haplotypes associated with adverse pregnancy outcomes and assess the causes of a large number of infection recurrences in this population group, discriminating between reinfection, recrudescence, and relapse. Consequently, clarifying the P. vivax biological aspects associated with gestational malaria may contribute to outline new strategies to treat the disease in pregnant women. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
IBRAHIM, AMY; MANKO, EMILIA; DOMBROWSKI, JAMILLE G.; CAMPOS, MONICA; BENAVENTE, ERNEST DIEZ; NOLDER, DEBBIE; SUTHERLAND, COLIN J.; NOSTEN, FRANCOIS; FERNANDEZ, DIANA; VELEZ-TOBON, GABRIEL; et al. Population-based genomic study of Plasmodium vivax malaria in seven Brazilian states and across South America. LANCET REGIONAL HEALTH-AMERICAS, v. 18, p. 21-pg., . (20/06747-4, 16/13465-0, 19/12068-5)
DOMBROWSKI, JAMILLE G.; SOUZA, RODRIGO M.; CURRY, JONATHAN; HINTON, LAURA; SILVA, NATERCIA R. M.; GRIGNARD, LYNN; GONCALVES, LIGIA A.; GOMES, ANA RITA; EPIPHANIO, SABRINA; DRAKELEY, CHRIS; et al. G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon. Malaria Journal, v. 16, . (12/04755-3, 14/20451-0, 14/09964-5, 15/06106-0, 16/13465-0)

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