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Nanomechanical test of a new 4th generation implant surface, modified by the addition of nano-hydroxyapatite: in vivo study in diabetic rats

Grant number: 16/14584-2
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): December 01, 2016
Effective date (End): November 30, 2017
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Sérgio Luís Scombatti de Souza
Grantee:Paula Gabriela Faciola Pessoa de Oliveira
Supervisor: Paulo Guilherme Gonçaalves Gomes Coelho
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: New York University, United States  
Associated to the scholarship:15/09879-0 - Evaluation of a new hydroxiapatite covered nanometric implant surface. An in vitro study in rats, BP.DR


Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia, resulting from defects in insulin secretion, insulin action, or both. The high prevalence of periodontitis and tooth loss in diabetic subjects represents an important health implication, and treatment with dental implants is considered a therapeutic strategy for replacing lost teeth in these patients. Diabetes has been considered a risky condition for dental implants, as it is associated to delayed wound healing, prevalence of microvascular disease and impaired response to infection. The microstructure and surface characteristics of dental implants have a direct influence on bone response, because they can affect protein adsorption and modulate cell proliferation and differentiation. Surface characteristics such as roughness, chemistry and energy have been reported to significantly influence cell differentiation, protein production and, consequently, bone growth and osseointegration. Thus, taking into account the development of new implant surfaces with processes aimed at qualitative and quantitative improvement of osseointegration phenomenon, and on the other hand the healing deficiency of DM, which can be used as models of subjects with impaired bone repair. The aim of this in vivo study is to evaluate the nanomechanical response of a new 4th generation implant surface, modified by the addition of nano-hydroxyapatite through nanoindentation test. The results are expressed as mean ± standard deviation of the groups in each period, considering the animal as experimental unit. Pre-tests will be performed to assess the normality of the data. Based on the results, the appropriate statistical tests to analyze differences between groups will be selected in each period (7 and 30 days), and intra-group, in relation to different times. In all analyzes, will be considered p <0.05. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, PAULA G. F. P.; COELHO, PAULO G.; BERGAMO, EDMARA T. P.; WITEK, LUKASZ; BORGES, CRISTINE A.; BEZERRA, FABIO B.; NOVAES, JR., ARTHUR B.; SOUZA, SERGIO L. S.. Histological and Nanomechanical Properties of a New Nanometric Hydroxiapatite Implant Surface. An In Vivo Study in Diabetic Rats. MATERIALS, v. 13, n. 24, . (16/14584-2, 15/09879-0)
DE OLIVEIRA, PAULA GABRIELA FACIOLA PESSOA; DE MELO SOARES, MARIANA SALES; SILVEIRA E SOUZA, ADRIANA MARIA MARIANO; TABA JR, MARIO; PALIOTO, DANIELA BAZAN; MESSORA, MICHEL REIS; GHIRALDINI, BRUNA; NUNES, FELIPE ANDERSON DE SOUSA; DE SOUZA, SERGIO LUIS SCOMBATTI. Influence of nano-hydroxyapatite coating implants on gene expression of osteogenic markers andmicro-CTparameters. An in vivo study in diabetic rats. Journal of Biomedical Materials Research Part A, v. 109, n. 5, . (16/14584-2, 15/09879-0)

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