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Low level lasertherapy action on morphometric and functional aspects at long term after skeletal muscle trauma in diabetic rats

Grant number: 16/11367-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2016
Effective date (End): September 30, 2017
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Rodrigo Leal de Paiva Carvalho
Grantee:Nathália Araujo Miguel
Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil


Aerobic and resistance exercise has been prescribed for the prevention and treatment of patients with Diabetes Mellitus (DM) due to improved glucose control and reduction of other risk factors. Traumatic muscle injuries are directly related to physical activity may cause functional loss and morphological changes in varying degrees. Different types of therapies, pharmacological and non-pharmacological, have been used in the treatment and recovery of musculoskeletal injuries, such as anti-inflammatory drugs and low level laser therapy. It is known that the process of rat skeletal muscle repair lasts about 28 days after injury, however little is known regarding the morphologic and functional recovery at the end of the muscle tissue repair process in a diabetic organism. The aim of this study is to evaluate the recovery of muscle tissue during and after the repair process (14 and 28 days), by morphometric and functional analysis after muscle injury trauma in diabetic rats, using as treatment low level laser therapy and diclofenac, alone or in combination. For injury induction the animals receive a single trauma in the right hind limb. The laser irradiation will be performed at only one point in the trauma area, at 3J energy dose for 30s. Diclofenac will be applied one hour after injury protocol, at a dose of 11.6 mg/g -1 (milligram gram) topically, locally. Morphometric and functional analysis of the muscle tissue will be performed at 14 and 28 days after injury induction. (AU)

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