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Effect of monounsaturated fatty acids consumption in brown/beige adipose tissue activity in human adults

Grant number: 16/10616-7
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2016
Effective date (End): January 31, 2021
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Licio Augusto Velloso
Grantee:Milena Monfort Pires
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID
Associated scholarship(s):19/02055-3 - Glucose uptake rate evaluated by dynamic PET/MRi as a method for determination of brown adipose tissue in humans - Potential association with brain activity, BE.EP.PD   18/05479-6 - Training on the determination of human brown adipose tissue using PET/MR images, BE.EP.PD


Considering the high prevalence of obesity its comorbidities in Brazil and in the world, different therapeutic measures have been suggested. It is currently known that brown/beige adipose tissue plays an important role in body weight control and there is strong evidence that its activity is inversely associated with obesity and metabolic diseases. Recent studies have shown an important role foods and nutrients in the activation of brown/beige adipose tissue, almost exclusively in animal models. The benefits of monounsaturated fatty acids to metabolism have been described in several studies, however, the effects of consuming large amounts of olive oil in the activity of brown/beige adipose tissue in humans have not been explored. The aim of the study is to evaluate the impact of the consumption of large amounts of extra virgin olive oil in the activity of brown/beige adipose tissue in lean and obese humans. This will be a clinical trial with a total duration of 4 weeks. Obese and controls (normal weight) participants will undergo a dietary intervention for 4 weeks with extra virgin olive oil. Before and after the intervention period several data will be collected: dietary intake and physical activity data, evaluation of brown/beige adipose tissue (with FDG PET / CT scan), assessment of body composition (DXA), lipid profile and inflammatory markers and hypothalamic inflammation (functional magnetic resonance imaging in a subsample). The data will be expressed as mean and standard deviation and the variables compared by the Student t test or ANOVA for repeated measures.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONFORT-PIRES, MILENA; U-DIN, MUEEZ; NOGUEIRA, GUILHERME A.; DE ALMEIDA-FARIA, JULIANA; SIDARTA-OLIVEIRA, DAVI; SANT'ANA, MARCELLA RAMOS; DE LIMA-JUNIOR, JOSE C.; CINTRA, DENNYS E.; DE SOUZA, HERALDO POSSOLO; FERREIRA, SANDRA R. G.; et al. Short Dietary Intervention with Olive Oil Increases Brown Adipose Tissue Activity in Lean but not Overweight Subjects. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. 106, n. 2, p. 472-484, . (16/10616-7, 19/02055-3, 18/05479-6)
MONFORT-PIRES, M.; SILVA, G. R.; DADSON, P.; NOGUEIRA, G. A.; U-DIN, M.; VIRTANEN, K. A.; VELLOSO, L. A.. Brown adipose tissue content of triglycerides, but not SUV, is associated with cardiovascular risk markers in volunteers from a tropical region. Diabetologia, v. 65, n. SUPPL 1, p. 1-pg., . (19/02055-3, 16/10616-7, 17/22586-8)
MONFORT-PIRES, MILENA; REGENI-SILVA, GIULIANNA; DADSON, PRINCE; NOGUEIRA, GUILHERME A.; U-DIN, MUEEZ; FERREIRA, SANDRA R. G.; SAPIENZA, MARCELO TATIT; VIRTANEN, KIRSI A.; VELLOSO, LICIO A.. Brown fat triglyceride content is associated with cardiovascular risk markers in adults from a tropical region. FRONTIERS IN ENDOCRINOLOGY, v. 13, p. 13-pg., . (17/22586-8, 19/02055-3, 13/07607-8, 18/05479-6, 16/10616-7)

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