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Effects of low-level laser therapy (LLLT) in experimental diabetic neuropathy

Grant number: 15/12673-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2016
Effective date (End): February 29, 2020
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Carlos Amilcar Parada
Grantee:Willians Fernando Vieira
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):18/05108-8 - Direct influence of low-level laser irradiation on neurons: an electrophysiological study to helping comprise analgesic effects of infrared light in diabetic neuropathy, BE.EP.DR


Diabetic neuropathy is manifested in about 60% of diabetic patients and is among the leading causes of amputation of peripheral members. Among the diagnosed cases of neuropathic pain, related to diabetic neuropathy is 30%. Although electrophysiological and morphological aspects of diabetic neuropathic pain are known, little is known about its development and progression, making difficult effective therapies. More recently, several studies have demonstrated a close correlation between the development of diabetic neuropathy and the increase of pro-inflammatory cytokines in the dorsal root ganglia (DRG), for example, the interleukin 1² (IL-1²) and tumor necrosis factor-alpha (TNF-±), which also act as signaling pathway activators of mitogen-activated protein kinases (MAPKs). Among other non-pharmacological therapies, low-level laser (light) therapy (LLLT) may be used as a treatment in cases of diabetic neuropathy. The results of clinical studies involving the effects of LLLT in the peripheral nervous system (PNS) are encouraging but inconclusive when it comes to pain of neuropathic origin in general. Little is known about the influence of LLLT activation and / or inhibition of signaling pathways related to diabetic neuropathy, such as the MAPK pathway (involving the p38 proteins, c-Jun N-terminal and ERK, and their phosphorylated forms). From this, the objective of this study will confirm the antihyperalgesic effect of LLLT in rats with diabetic neuropathy induced by systemic administration of streptozotocin. That said, we check whether the antihyperalgesic effect expected with this non-drug therapy is correlated with decreased levels of proinflammatory cytokines such as IL-1² and TNF-±, and expression of MAPK (p38, c- Jun N-terminal and ERK) in DRG.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIEIRA, WILLIANS F.; DE MAGALHAES, SILVIANE F.; FARIAS, FELIPE H.; DE THOMAZ, ANDRE A.; PARADA, CARLOS A.. Raman spectroscopy of dorsal root ganglia from streptozotocin-induced diabetic neuropathic rats submitted to photobiomodulation therapy. Journal of Biophotonics, v. 12, n. 11, . (15/12673-5, 14/25153-7, 18/05108-8)
VIEIRA, WILLIANS FERNANDO; MALANGE, KAUE FRANCO; DE MAGALHAES, SILVIANE FERNANDES; PAES LEMES, JULIA BORGES; DOS SANTOS, GILSON GONCALVES; NISHIJIMA, CATARINE MASSUCATO; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE; DA CRUZ-HOFLING, MARIA ALICE; PARADA, CARLOS AMILCAR; TAMBELI, CLAUDIA HERRERA. Anti-hyperalgesic effects of photobiomodulation therapy (904 nm) on streptozotocin-induced diabetic neuropathy imply MAPK pathway and calcium dynamics modulation. SCIENTIFIC REPORTS, v. 12, n. 1, p. 18-pg., . (18/05108-8, 15/12673-5, 14/25153-7)
VIEIRA, WILLIANS FERNANDO; MALANGE, KAUE FRANCO; DE MAGALHAES, SILVIANE FERNANDES; DOS SANTOS, GILSON GONCALVES; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE; CRUZ-HOFLING, MARIA ALICE; PARADA, CARLOS AMILCAR. Gait analysis correlates mechanical hyperalgesia in a model of streptozotocin-induced diabetic neuropathy: A CatWalk dynamic motor function study. Neuroscience Letters, v. 736, p. 12-pg., . (15/12673-5, 14/25153-7, 18/05108-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
VIEIRA, Willians Fernando. Effects of low-level laser therapy (LLLT) in experimental diabetic neuropathy. 2020. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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