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Consequences of neonatal inflammatory nociceptive stimulation on sleep patterns of adult rats

Grant number: 16/04848-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Luciene Covolan
Grantee:Jade Cardoso Muniz
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Invasive painful procedures are often performed in neonates admitted into intensive care units (ICU). The acute and long-term stimulation caused by these procedures can be investigated in animal models, such as newborn rats. Previous studies have shown that animals subjected to neonatal noxious stimulation, in adulthood may do not cope with stressful situations. These can bring out behavioral manifestations that once were in latent state; and stressful events in critical periods of development can undermine the resilience mechanisms to stress. In this scenario, this study proposes to use neonatal nociceptive stimulation (induced in the first or eighth day after birth, with the intraplantar injection of CFA Freund's adjuvant -complete) to analyze sleep parameters (macro and micro-architecture) at baseline conditions, post-stress and after the sleep deprivation (homeostatic response) in adulthood.

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