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Study of Detoxification Enzymes Interaction with chemotherapeutic drugs and its relationship with chemoresistance

Grant number: 16/00991-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2016
Effective date (End): July 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Ronaldo Censi Faria
Grantee:Elsa María Materón Vásques
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):18/00749-5 - Biosensor to detect chemotherapeutic drugs related to chemoresistance, BE.EP.PD


The therapeutic efficacy of drugs widely used in cancer treatments for a range of different types of cancerous tumor and other pathologies are found to be affected by intrinsic or acquired resistance that may develop during the treatment, and this has in essence become one of the most crucial problems of medicine, more specifically in therapy against cancer. It is in this light that the development of analytical methods aiming at monitoring the chemotherapy resistance and consequently the monitoring of the effectiveness of anticancer drugs stand to be of imperative relevance and of great interest once they play a major role in improving clinical treatments. This can be attained through the study of the action mechanism and the properties of detoxification enzymes that can be used in devices for the detection of problems related to drug metabolism. Therefore, the overall objective of the project lies in studying the action mechanism of detoxification enzymes such as metalotionenina, cytochrome P450, and glutathione-S-transferase present in the metabolism of neoplastic drugs, and this knowledge once acquired will be implemented in the simultaneous detection of platinum compounds (cisplatin), methotrexate, tamoxifen, doxorubicin and gemcitabine in modified screen-printed multichannel electrodes and field-effect transistors and thus contributing towards the improvement of chemotherapy treatments.

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PROENCA, CAMILA A.; BALDO, THAISA A.; FREITAS, TAYANE A.; MATERON, ELSA M.; WONG, ADEMAR; DURAN, ANDRES A.; MELENDEZ, MATIAS E.; ZAMBRANO, GUSTAVO; FARIA, RONALDO C.. Novel enzyme-free immunomagnetic microfluidic device based on Co0.25Zn0.75Fe2O4 for cancer biomarker detection. Analytica Chimica Acta, v. 1071, p. 59-69, . (17/24053-7, 15/19890-1, 16/00991-5)
MATERON, ELSA MARIA; MARCHETTO, REINALDO; ARAUJO, ANGELA REGINA; VEGA-CHACON, JAIME; PIVIDORI, I, MARIA; JAFELICCI JR, MIGUEL; SHIMIZU, FLAVIO M.; OLIVEIRA JR, OSVALDO N.; BOLDRIN ZANONI, MARIA VALNICE. A simple electrochemical method to monitor an azo dye reaction with a liver protein. Analytical Biochemistry, v. 553, p. 46-53, . (13/14262-7, 12/15543-7, 16/00991-5)
PROENCA, CAMILA A.; FREITAS, TAYANE A.; BALDO, THAISA A.; MATERON, ELSA M.; SHIMIZU, FLAVIO M.; FERREIRA, GABRIELLA R.; SOARES, FREDERICO L. F.; FARIA, RONALDO C.; OLIVEIRA JR, OSVALDO N.. Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors. BEILSTEIN JOURNAL OF NANOTECHNOLOGY, v. 10, p. 2171-2181, . (13/14262-7, 16/00991-5)
MATERON, ELSA M.; MIYAZAKI, CELINA M.; CARR, OLIVIA; JOSHI, NIRAV; PICCIANI, PAULO H. S.; DALMASCHIO, CLEOCIR J.; DAVIS, FRANK; SHIMIZU, FLAVIO M.. Magnetic nanoparticles in biomedical applications: A review. APPLIED SURFACE SCIENCE ADVANCES, v. 6, . (14/23546-1, 18/22214-6, 16/00991-5)
IBANEZ-REDIN, GISELA; FURUTA, ROBERTO H. M.; WILSON, DEIVY; SHIMIZU, FLAVIO M.; MATERON, ELSA M.; REBOLHO BATISTA ARANTES, LIDIA MARIA; MELENDEZ, MATIAS E.; CARVALHO, ANDRE L.; REIS, RUI MANUEL; CHAUR, MANUEL N.; et al. Screen-printed interdigitated electrodes modified with nanostructured carbon nano-onion films for detecting the cancer biomarker CA19-9. Materials Science & Engineering C-Materials for Biological Applications, v. 99, p. 1502-1508, . (17/12096-3, 13/14262-7, 16/00991-5, 12/15543-7, 15/01770-0)
BALDO, THAISA APARECIDA; PROENCA, CAMILA DOS ANJOS; FELIX, FABIANA DA SILVA; FREITAS, TAYANE AGUIAR; SAKATA, SOLANGE KAZUMI; ANGNES, LUCIO; FARIA, RONALDO CENSI. Disposable electrochemical microfluidic device for ultrasensitive detection of egg allergen in wine samples. Talanta, v. 232, . (16/00991-5, 17/24053-7, 17/13137-5, 14/50867-3, 13/14262-7)
FREITAS, TAYANE A.; PROENCA, CAMILA A.; BALDO, THAISA A.; MATERON, ELSA M.; WONG, ADEMAR; MAGNANI, RODRIGO F.; FARIA, RONALDO C.. Ultrasensitive immunoassay for detection of Citrus tristeza virus in citrus sample using disposable microfluidic electrochemical device. Talanta, v. 205, . (16/00991-5, 17/24053-7, 15/19890-1)
MATERON, ELSA M.; SHIMIZU, FLAVIO M.; DOS SANTOS, KEVIN FIGUEIREDO; NASCIMENTO, GUSTAVO F.; GERALDO, VANANELIA P. N.; OLIVEIRA JR, OSVALDO N.; FARIA, RONALDO C.. Membrane model as key tool in the study of glutathione-s-transferase mediated anticancer drug resistance. BIOMEDICINE & PHARMACOTHERAPY, v. 145, . (12/15543-7, 17/24053-7, 16/00991-5, 18/22214-6)
MEJIA-SALAZAR, JORGE RICARDO; CRUZ, KAMILLA RODRIGUES; MATERON VASQUES, ELSA MARIA; DE OLIVEIRA, JR., OSVALDO NOVAIS. Microfluidic Point-of-Care Devices: New Trends and Future Prospects for eHealth Diagnostics. SENSORS, v. 20, n. 7, . (13/14262-7, 16/00991-5)

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