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Role of Muscle Ceramides on Mitochondrial Function and Insulin Action

Grant number: 16/07151-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): October 01, 2016
Effective date (End): September 30, 2017
Field of knowledge:Health Sciences - Dentistry - Social and Preventive Dentistry
Principal researcher:Doris Hissako Matsushita
Grantee:Renato Felipe Pereira
Supervisor abroad: Scott Andrew Summers
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
Research place: University of Utah (U), United States  
Associated to the scholarship:14/17619-6 - STUDY ABOUT THE MECHANISMS INVOLVED IN THE DEVELOPMENT OF INSULIN RESISTANCE IN RATS WITH PERIAPICAL LESION, BP.DR

Abstract

Circulating sphingolipids are associated with insulin resistance and type 2 diabetes in humans. Plasma ceramides are higher in obese children and diabetic adults and correlate with the severity of insulin resistance. Therefore to explore the hypothesis that ceramides or related sphingolipids serve as nutritional cues to alter mitochondrial function and substrate preference is very important. In addition to resolving lingering controversies about muscle adaptation to nutrient availability, these studies could uncover novel therapeutic targets for combating insulin resistance associated with obesity. The present study aims to: 1) To determine to whether genetic disruption of serine palmitoyltransferase and dihydroceramide desaturase in skeletal muscle impacts peripheral insulin sensitivity, metabolic flexibility, and mitochondrial function. 2) To determine the mechanisms by which ceramides and ceramide metabolites influence mitochondrial function and insulin action.

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