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Differences in the composition of the acquired pellicle in pacients with gastroesophageal reflux disease with and without dental erosion: proteomic study

Grant number: 14/26606-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): July 01, 2016
Effective date (End): March 31, 2017
Field of knowledge:Health Sciences - Dentistry - Social and Preventive Dentistry
Principal Investigator:Marília Afonso Rabelo Buzalaf
Grantee:Tatiana Martini
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


This study will compare the protein profile of acquired enamel pellicle (AEP) formed in vivo in GERD patients with or without dental erosion and control patients. We have a 3-arm parallel design, where 30 volunteers will be divided into 3 groups, as follows: a) GERD patients with dental erosion (BEWE e 3); GERD patients without dental erosion (BEWE = 0); c) control patients (without GERD; BEWE = 0). Volunteers (n=10/group) will be submitted to dental prophylaxis and AEP will be allowed to form for 120 min. AEP will be collected with wick filters pre-soaked in 3% citric acid. A pool with the filters obtained from 10 volunteers from the same group will be done. After protein extraction, samples will be submitted to reverse phase liquid chromatography coupled to mass spectrometry (nLC-ESI-MS/MS). Label-free proteomic quantification will be performed using Protein Lynx Global Service (PLGS) software.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINI, TATIANA; RIOS, DANIELA; SILVA CASSIANO, LUIZA PAULA; DE SOUZA SILVA, CINTIA MARIA; TAIRA, EVEN AKEMI; SILVA VENTURA, TALITA MENDES; BARBOSA SILVA PEREIRA, HELOISA APARECIDA; MAGALHAES, ANA CAROLINA; CARVALHO, THIAGO SAADS; BAUMANN, TOMMY; et al. Proteomics of acquired pellicle in gastroesophageal reflux disease patients with or without erosive tooth wear. Journal of Dentistry, v. 81, p. 64-69, . (14/26606-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARTINI, Tatiana. Proteomics of acquired enamel pellicle in volunteers with gastroesophageal reflux with dental erosion or not. 2017. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB) Bauru.

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