Grant number: | 16/08470-4 |
Support Opportunities: | Scholarships in Brazil - Doctorate |
Start date until: | August 01, 2016 |
End date until: | June 30, 2019 |
Field of knowledge: | Health Sciences - Pharmacy - Medicines Analysis and Control |
Principal Investigator: | Chung Man Chin |
Grantee: | Diego Eidy Chiba |
Host Institution: | Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil |
Associated scholarship(s): | 17/13524-9 - Design, synthesis and biological evaluation of new derivatives of LAPDESF FTD-AO and LAPDESF FTD-TAU series with potential activity in the treatment of Alzheimer's Disease, BE.EP.DR |
Abstract Alzheimer's disease (AD) is the main and most common cause of senile dementia, responsable for 50-75% of diagnosed cases. In developed countries, AD is the fourth cause of death, only behind of cardiovascular disease, cancer and stroke. The projection of the World Health Organization (WHO) is that by 2050 the number of elderly will increase 21% in the world. AD is a progressive neurodegenerative disease, in which patients diagnosed show an extensive loss of synapses and neurons in the hippocampus and frontal and temporal cortex, compromising gradually his cognitive functions such as memory, learning ability, thinking, besides of the impairment of communication skills and performance of daily activities. Currently there is no treatment able to cure or modify effectively the disease, only medications (tacrine, donepezil, rivastigmine, galantamine and memantine) that improve some symptoms manifested by patients. It is therefore of great importance to find and develop new therapeutic approaches and new drugs able to delay or prevent the progression of the disease. Because of the described, this project aims to obtain two series of novel drug candidates with anti-inflammatory / neuroprotective activities, using molecular hybridization of lipoic acid or ferulic acid with phtalimide derivatives (first series containing phenyl group and the second series containing the amino acid taurine), mainly by exploiting the properties of TNF-± inhibition, microtubule stabilizing and antioxidant. The reduction in the process of neuroinflammation and oxidative stress associated with aging and DA biomarkers, such as the formation of senile plaques and neurofibrillary tangles, contributes to synaptic plasticity, cognition and memory, which mitigate the effects associated with neuronal loss in AD patients | |
News published in Agência FAPESP Newsletter about the scholarship: | |
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