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Evaluation of bone repair in the bone/implant interface in estrogen deficient famale rats untreated and treated with strontium ranelate - analysis three dimensional microtomography and immunohistochemistry

Grant number: 16/03790-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2016
Effective date (End): December 31, 2017
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Roberta Okamoto
Grantee:Fernanda Costa Yogui
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The purpose of this study is to evaluate the peri implant bone repair in rats submitted to ovariectomy and treated with Strontium ranelate (625mg / kg / day). Thirty-six (36) female rats, weighing approximately 300 grams, will be divided into 3 groups according to drug treatment: SHAM group, 12 rats submitted to sham surgery; OVX group, 12 rats submitted to ovariectomy surgery and without drug treatment; Group RAN-Sr, 12 rats submitted to ovariectomy surgery and treated with Strontium ranelate. Each animal will receive 2 implants with 1 in each tibial metaphysis. The analyzes to be performed are the microtomography three-dimensional (Micro-CT) and immunohistochemistry for immunoblotting of proteins that characterize the osteoblast differentiation process (will be evaluated RUNX-2, osteopontin and osteocalcin) and alkaline phosphatase. The quantitative data will be subjected to statistical test of normality and homoscedasticity, applied a parametric or non-parametric test. For all data is considered to be 5% significance level.

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