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The role of miRNAs in mononuclear cells infection of peripheral blood and spleen leukocytes the dog by Leishmania infantum

Grant number: 15/16101-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2016
Effective date (End): December 31, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Valéria Marçal Felix de Lima
Grantee:Larissa Martins Melo
Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The visceral leishmaniasis (VL) in man is a chronic and often fatal disease if left untreated and is booming with an increase also in the state of São Paulo. According to Secretary of Epidemiological Surveillance of the State of São Paulo, the disease is expanding with high mortality rate, and the Araçatuba region concentrates a large number of state affairs. The canine VL is a serious public health problem, because the infected animals are potent transmitters of the parasite to humans by the vector flebotomínio and canine disease is more prevalent than the human disease, usually canines cases precede human cases. The dog is therefore an important target in the control measures. The progression of canine infection is accompanied by a failure of cellular immunity in reducing circulating lymphocytes and cytokines that suppress macrophage function. The function of the T cell in the cellular response induced is decisive for elimination of the parasite in macrophages. Although immune suppression is already characterized, the determining factors are not well known. In the last decade studies have shown that regulation of effector function of macrophages and T cells appears to depend miRNAs. There are many evidences of the role of miRNA in regulating the expression of proteins that are critical for the development, function and differentiation of various cell types of the immune system. A deregulation of expression of the miRNA is involved in a variety of disorders including visceral leishmaniasis. In LVC cell immune suppression due to be determinant of disease progression, knowledge of miRNAs associated with immune regulation may be important for the response pattern of change. The objective of this research is to improve our understanding of the pathogenesis of visceral leishmaniasis in the host, and as such reveal new paths that can be therapeutic targets.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRAGATO, JAQUELINE POLETO; MELO, LARISSA MARTINS; VENTURIN, GABRIELA LOVIZUTTO; REBECH, GABRIELA TORRES; GARCIA, LEANDRO ENCARNACAO; LOPES, FLAVIA LOMBARDI; FELIX DE LIMA, VALERIA MARCAL. Relationship of peripheral blood mononuclear cells miRNA expression and parasitic load in canine visceral leishmaniasis. PLoS One, v. 13, n. 12, . (15/16972-7, 16/02359-4, 15/16101-6)
MELO, LARISSA MARTINS; BRAGATO, JAQUELINE POLETO; VENTURIN, GABRIELA LOVIZUTTO; REBECH, GABRIELA TORRES; COSTA, SIDNEI FERRO; GARCIA, LEANDRO ENCARNACAO; LOPES, FLAVIA LOMBARDI; EUGENIO, FLAVIA DE REZENDE; PATTO DOS SANTOS, PAULO SERGIO; FELIX DE LIMA, VALERIA MARCAL. Induction of miR 21 impairs the anti-Leishmania response through inhibition of IL-12 in canine splenic leukocytes. PLoS One, v. 14, n. 12, . (18/16239-6, 15/16972-7, 15/16101-6)
SOARES, MATHEUS FUJIMURA; MELO, LARISSA MARTINS; BRAGATO, JAQUELINE POLETO; FURLAN, AMANDA DE OLIVEIRA; SCARAMELE, NATALIA FRANCISCO; LOPES, FLAVIA LOMBARDI; FELIX DE LIMA, VALERIA MARCAL. Differential expression of miRNAs in canine peripheral blood mononuclear cells (PBMC) exposed to Leishmania infantum in vitro. Research in Veterinary Science, v. 134, p. 58-63, . (15/16101-6, 15/16972-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MELO, Larissa Martins. The role of mirna in the infection of dog spleen leukocytes by Leishmania Infantum. 2018. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.

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