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Study of gene alterations in samples of uterine sarcomas and uterine carcinosarcomas: Identification of markers for differential diagnosis and treatment

Grant number: 16/03163-6
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): July 01, 2016
Effective date (End): December 31, 2017
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Kátia Cândido Carvalho
Grantee:Leonardo Tomiatti da Costa
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Uterine sarcomas are rare mesodermal tumors that comprise approximately 3% of all cancers in this organ. They commonly show histologic diversity and aggressive behavior, with early spread and high mortality rates. Although carcinosarcomas (CS) have been reclassified recently as carcinomas, we included them in our sample for comparison purposes. Because of its diversity and rarity, there is no consensus related to the risk factors for poor prognosis and appropriate treatment for these tumors. In this context, informations about their genetic and protein profiles can help in these tumors diagnosis and prognosis as well as the understanding of its biology and clinical behavior. The objective of this project is to verify the presence of genetic alterations in 200 genes with participationin in cancinogenesis process in different types of uterine sarcomas and CS, for discovery of potential biological markers for each of these neoplasias. In addition, it intends to evaluate the effect of these changes in the protein expression. We will to perform the Ion Torrent platform analysis in paraffin-embedded material (using the AmpliSeq method, Life Technologies). In total, it will be evaluated 100 samples of uterine sarcomas and CS (including: 56 leiomyosarcomas, 15 endometrial stromal sarcomas, 3 sarcomas undifferentiated, 2 adenossarcomas and 24 CS). Tissues were provided by the Hospital Santa Marcelina, Instituto Brasileiro de Combate ao Cancer (IBCC) and Instituto do Cancer do Estado de São Paulo (ICESP), all in São Paulo, Brazil. Validations will be performed by immunohistochemistry. All data will be submitted to statistical analysis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEONARDO TOMIATTI DA COSTA; LAURA GONZALEZ DOS ANJOS; LUCIANE TSUKAMOTO KAGOHARA; GIOVANA TARDIN TORREZAN; CLAUDIA A. ANDRADE DE PAULA; EDMUND CHADA BARACAT; DIRCE MARIA CARRARO; KATIA CANDIDO CARVALHO. The mutational repertoire of uterine sarcomas and carcinosarcomas in a Brazilian cohort: A preliminary study. Clinics, v. 76, . (19/01109-2, 16/03163-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COSTA, Leonardo Tomiatti da. Study of gene alterations in uterine sarcomas and carcinosarcoma samples. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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