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Characterization of the mechanisms underlying omega-3 fatty acids effects on energy balance

Grant number: 16/07062-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): July 01, 2016
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:William Tadeu Lara Festuccia
Grantee:Tiago Eugênio Oliveira da Silva
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/19530-5 - Involvement of the nutrient sensor mTOR in the development of obesity associated chronic metabolic diseases, AP.TEM

Abstract

Recent studies from our laboratory have shown that increased body content of omega 3 (n-3) fatty acids, through the intake of a diet rich in fish oil or expression of fat-1 desaturase which converts omega 6 to n-3, protect mice from diet induced obesity, inflammation and glucose intolerance. Interestingly, such protection from obesity induced by n-3 fatty acids occur independently of changes in food intake, indicating a likely involvement of energy expenditure as a underlying cause. Herein we will test the hypothesis that n-3 fatty acids enhance energy expenditure in mice through the modulation of uncoupling protein-1 (UCP-1) dependent and independent thermogenesis. To test this hypothesis we will perform two different protocols: first we will assess the effects of different concentrations of n-3 fatty acids on C57BL/6J mice body weight, energy balance, adiposity, energy expenditure, sympathetic activity to brown and white adipose tissue, mitochondrial content and function, hypothalamus-pituitary-thyroid status, body temperature, and brown and white adipose tissues morphology, contents of UCP1, deiodinase type 2, SERCA 1 e 2, and other thermogenesis- related proteins. In the second protocol, we will evaluated the same parameters in wild-type and UCP-1 deficient mice fed with a regular high-fat diet or a fish oil enriched diet to investigate the contribution of nonshivering thermogenesis to the increase in energy expenditure induced by n-3 fatty acids. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASTRO, ERIQUE; SILVA, TIAGO E. OLIVEIRA; FESTUCCIA, WILLIAM T.. Critical review of beige adipocyte thermogenic activation and contribution to whole-body energy expenditure. HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, v. 31, n. 2, SI, . (15/19530-5, 16/23169-9, 16/07062-0)
OLIVEIRA, TIAGO E.; CASTRO, ERIQUE; BELCHIOR, THIAGO; ANDRADE, MAYNARA L.; CHAVES-FILHO, ADRIANO B.; PEIXOTO, ALBERT S.; MORENO, MAYARA F.; ORTIZ-SILVA, MILENE; MOREIRA, RAFAEL J.; INAGUE, ALEX; et al. Fish Oil Protects Wild Type and Uncoupling Protein 1-Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure. MOLECULAR NUTRITION & FOOD RESEARCH, v. 63, n. 7, . (16/23169-9, 15/19530-5, 17/17582-3, 15/22983-1, 17/12260-8, 18/11156-5, 17/23040-9, 15/13508-8, 16/07062-0)
BLANCHARD, PIERRE-GILLES; MOREIRA, RAFAEL J.; CASTRO, ERIQUE; CARON, ALEXANDRE; COTE, MARIE; ANDRADE, MAYNARA L.; OLIVEIRA, TIAGO E.; ORTIZ-SILVA, MILENE; PEIXOTO, ALBERT S.; DIAS, FRANCE ANNE; et al. PPAR gamma is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 89, p. 27-38, . (16/23169-9, 15/19530-5, 17/12260-8, 15/13508-8, 16/07062-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Tiago Eugênio Oliveira da. Intake of diet enriched fish oil increases energy expenditure by a UCP1-independent mechanism and protects mice from obesity induced by lard-rich diet.. 2018. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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