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Suitability and follow-up by elastography in dogs with hyperadrenocorticism under trilostane therapy

Grant number: 16/07491-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2016
Effective date (End): September 04, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Áureo Evangelista Santana
Grantee:Juliana Aparecida Do Carmo Emidio e Silva
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated scholarship(s):16/17543-5 - Research stage to the University of California - Davis, United States, BE.EP.IC

Abstract

The aim of this study is to evaluate the applicability of monitoring by ARFI (Acoustic Radiation Force Impulse) elastography of adrenal glands of dogs with hyperadrenocorticism pituitary-dependent (PDH) during treatment with trilostane. Experimental groups will be compound by at least 6 dogs with a diagnosis of PDH from Veterinary Teaching Hospital "Governador Laudo Natel" of Faculty of Agricultural and Veterinary Sciences of Unesp - campus of Jaboticabal, SP. After laboratory and clinical examinations such as hormonal tests, the dogs will be subjected to a conventional ultrasound examination, quantitative and qualitative ARFI elastography using ACUSON S2000/SIEMEN ultrasound and specific software. Dogs with PDH will be followed-up during treatment with trilostane at 3 and 6 months after initial evaluation. Blind methodology will be used and a 5% significance level for all tests will be applied. The significance of elastography will be obtained at the time of PDH diagnosis, and their suitability to monitoring of the adrenal glands during treatment with trilostane will be obtained by comparison with previous assessments.

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