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In situ evaluation of a dentifrice containing calcium silicate, phosphate and fluoride in the prevention of erosive and abrasive wear

Grant number: 15/23911-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2016
Effective date (End): December 31, 2016
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Daniela Rios Honório
Grantee:Isabela Maníglia Mesquita
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


In recent decades we could observe an increasing prevalence of dental erosion and that some products are being launched in the market for treating this condition. Among them, we can mention the dentifrice containing calcium silicate, phosphate and fluoride which promises the recovery of the mineral composition of the tooth with 1 week of consecutive use. However, there are no investigations evaluating wear which can occur when compared to the erosive challenges associated with abrasion. Therefore, this study aims evaluate in situ the effectiveness of the application of toothpaste in preventing erosive wear, considering the episodes of erosion and / or abrasion of the enamel. Using a protocol in situ after the making of the blocks Bovine teeth enamel, the surface hardness will be performed to check the samples and the analysis of the profile initial. Therefore, the samples will be distributed in intraoral devices to be used by 12 invited participants previously selected. The study groups will be: GI erosion and use of tooth paste calcium silicate (REGENERATE Enamel Science "); GII + erosion and abrasion use of toothpaste with silicate calcium (REGENERATE Enamel Science "); GIII erosion and use of elmex® EROSION PROTECTION toothpaste; GIVerosão+ Abrasion and use of elmex® EROSION PROTECTION toothpaste; GV erosion and use of Colgate toothpaste Maximum anticaries protection; GVI- erosion + abrasion and use of toothpaste Colgate Maximum anticaries protection ; GVII - erosion without application of toothpaste; GIX- erosion + abrasion without application of toothpaste. The study will be 4 cross conducted on 7-day phases with a pause of 7 days between phases. In both phases voluntary apply the dentifrice in the specimens studied twice daily (morning and evening) and the abrasion of the groups Brushing is performed for all groups take place following the device immersion in acidic drink 4 times a day for 5 minutes. The results will be evaluated by perfilométrica analysis (initial and after cyclingerosive) by means of graphical and subjected to appropriate statistical analysis overlapping, considering the factors studied. The significance level for all tests will be 5%.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
IONTA, FRANCINY QUEROBIM; DOS SANTOS, NATALIA MELLO; MESQUITA, ISABELA MANIGLIA; DIONISIO, EVANDRO JOSE; CRUVINEL, THIAGO; HONORIO, HEITOR MARQUES; RIOS, DANIELA. Is the dentifrice containing calcium silicate, sodium phosphate, and fluoride able to protect enamel against chemical mechanical wear? An in situ/ex vivo study. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 10, p. 3713-3720, . (15/23911-4, 15/26520-6, 15/21552-7)

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