Advanced search
Start date

Bone healing evaluation in the bone / implant interface in estrogen deficient rats treated with human OPG-Fc or Strontium ranelate . Histometric, immunohistochemistry, biomechanics, computed microtomography and confocal microscopy analysis

Grant number: 15/13712-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2016
Effective date (End): May 31, 2018
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Roberta Okamoto
Grantee:Juliana Zorzi Coléte
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


This study will evaluate the peri-implant bone healing in rats submitted to ovariectomy and treated with strontium ranelate (625mg / kg / day) or OPG-Fc (10 mg / kg / 2 times per week). Eighty rats, 300 g, will be divided into six experimental groups according to the osteoporosis treatment: SHAM / SAL; OVX / SAL; OVX / RE; SHAM / SH; OVX / SH; OVX / OPG-Fc. Each animal will receive two implants on each tibia metaphysis. Euthanasia will be at 42 and 60 days after implants placement. The three-dimensional microtomography will be performed (micro CT), biomechanical (reverse torque) histometric, confocal laser microscopy, analysis of gene expression by real-time PCR, histological and immunohistochemical of proteins that characterize the bone remodeling process (OPG, osteocalcin, RANKL, TRAP) and Wnt pathway. Quantitative data will be submitted to statistical normality and homoscedasticity tests, applied a parametric or nonparametric test. For all data will be regarded 5% significance level.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

Please report errors in scientific publications list using this form.