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Study of the internalization of macromolecules in erythrocytes infected with Plasmodium falciparum

Grant number: 15/00689-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2016
Effective date (End): June 30, 2019
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Adriana Karaoglanovic Carmona
Grantee:Sarah El Chamy Maluf
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


In 2015, the World Health Organization reported 214 million cases of malaria distributed worldwide, with approximately 438,000 deaths. During its life cycle, the malaria parasite invades vertebrate host erythrocytes , where a single parasite reproduces asexually producing 16 to 32 for parasites. The high rate of intra-erythrocytic proliferation is dependent on the uptake of a series of essential nutrients from the host cell cytoplasm and plasma. The process of internalization of macromolecules by the parasite is complex, due to the passage of three membrane, namely the erythrocyte, parasitophorous vacuole and the parasite itself. It is widely recognized that the malaria parasite uptake nutrients of low molecular weight, such as polyols, amino acids, lipids, nucleosides, organic anions and cations in plasma. However, the mechanism used in the uptake of macromolecules remains the subject of debate. To better understand the import of plasma proteins by the parasite in this project, kininogen and plasminogen will be used as a model for study of the uptake of macromolecules. Understanding the cellular mechanisms of the protein intake, which can serve as an additional source of amino acids for the development of the parasite, might provide new elements to the understanding of the changes caused by the parasite in the host and a possible intervention in the Plasmodium life cycle in the host vertebrate can be achieved.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES SMAUL, MAYRIM MACHADO; BUDU, ALEXANDRE; MONTAGNA, GEORGINA NURI; DA SILVA FERRARA, TAISE FERNANDA; MALUF, SARAH EL CHAMY; BAGNARESI, PIERO; FERREIRA MACHADO, MARCELO MARCONDES; DOS SANTOS, FELLIPE BRONZE; DE AZEVEDO, MAURO FERREIRA; CARMONA, ADRIANA KARAOGLANOVIC; et al. Plasmodium falciparum histidine triad protein and calmodulin modulates calcium homeostasis and intracellular proteolysis. Biochemical and Biophysical Research Communications, v. 503, n. 2, p. 722-728, . (12/24278-5, 16/15298-3, 14/07138-0, 16/02412-2, 15/19316-3, 13/12913-0, 15/00689-4, 15/11861-2, 15/07182-2, 11/20941-9)

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