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Functional characterization of the translation factor EIF5A isoform A

Grant number: 13/23620-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2016
Effective date (End): September 30, 2019
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Augusto Ducati Luchessi
Grantee:Karina Danielle Pereira
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated research grant:10/18095-0 - Study of the eukaryotic translation initiation factor 5A (eIF5A) in mammals, AP.JP
Associated scholarship(s):17/11534-7 - Analysis of eIF5A in the context of insulin sensitivity, BE.EP.DR

Abstract

The eukaryotic translation initiation factor 5A (EIF5A) protein is highly conserved in eukaryotes. Some studies have showed that EIF5A has important roles in cell proliferation control and HIV-1 replication. EIF5A possesses a particular amino acid residue named hypusine that is not found in others proteins. The hypusine is essential for its activity and is produced by a post-translational modification using spermidine as substrate. The EIF5A protein has been involved with the protein synthesis process and recently it was showed that it acts on translation of polyproline motifs. In humans, five transcript variants for EIF5A are known (variants A, B, C, D and X5), derived from alternative splicing associated with the first exon. The variants B, C, D and X5 produce the isoform B, the main studied isoform at the moment. It is predicted that the variant A is responsible for the establishment of an upstream start codon in frame to the start codon of the other variants. Currently, there is no other information on EIF5A isoform A and this project aims to investigate its function.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
EDALATI, PARISA; FLORIANO, RICARDO; TANG, YONGPENG; MOHAMMADI, ABBAS; PEREIRA, KARINA DANIELLE; LUCHESSI, AUGUSTO DUCATI; EDALATI, KAVEH. Ultrahigh hardness and biocompatibility of high-entropy alloy TiAlFeCoNi processed by high-pressure torsion. Materials Science & Engineering C-Materials for Biological Applications, v. 112, . (18/15968-4, 13/23620-4)
PEREIRA, KARINA D.; TAMBORLIN, LETICIA; DE LIMA, I, TANES; CONSONNI, SILVIO R.; SILVEIRA, LEONARDO R.; LUCHESSI, AUGUSTO D.. Alternative human eIF5A protein isoform plays a critical role in mitochondria. Journal of Cellular Biochemistry, v. 122, n. 5, . (17/21914-1, 13/23620-4, 19/06951-3, 10/18095-0)
GOMES DE PROENCA, ANDRE RICARDO; PEREIRA, KARINA DANIELLE; MENEGUELLO, LETICIA; TAMBORLIN, LETICIA; LUCHESSI, AUGUSTO DUCATI. Insulin action on protein synthesis and its association with eIF5A expression and hypusination. MOLECULAR BIOLOGY REPORTS, v. 46, n. 1, p. 587-596, . (14/27154-0, 10/18095-0, 17/21914-1, 13/23620-4, 13/20504-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEREIRA, Karina Danielle. Functional characterization of isoform A of eukaryotic translation initiation factor 5A (eIF5A). 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Rio Claro Rio Claro.

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