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Linically suspected neuromyelitis optica associated to anti-MOG antibodies

Grant number: 15/23968-6
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2016
Effective date (End): January 01, 2018
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Dagoberto Callegaro
Grantee:Luana Michelli Oliveira de Paula Salles
Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Since MOG antibody has been described, it was associated with many demyelinated diseases like ADEM, pediatric MS, NMO, Neuromyelitis Optica Spectrum Disorders (NMOSD), isolated myelitis and optic neuritis. The role of MOG antibodies is yet unclear. Although MOG antibodies have been shown to be potentially pathogenic and to efficiently activate complement in-vitro small scale studies, earlier studies used ELISA and western-blot, so it is possible that less specific MOG antibody assays have added some confounding factors into some previous studies. Currently, the experience with cell-based assays to test MOG antibodies sounds promising to evaluate the utility of MOG antibodies as a biomarker in the clinical practice. Further studies evaluating the recognition of MOG epitopes and pathogenicity by these antibodies including a broader number of inflammatory idiopathic CNS disorders, such as MS, ADEM, AQP4 antibody seronegative NMOSD, and isolated optic neuritis may clarify whether patients with MOG antibodies may have a common immunopathological mechanism or multiple immune dysfunctions resulting in the same autoantibody. In our work we aim to describe optic neuritis ON, Longitudinally Extensive Transverse Myelitis (LETM), MOSD, NMO associated to MOG antibodies and describe the disease phenothype (recurrent x single attack) associated to MOG antibodies and antibodies titles bnehavior. (AU)

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Publicações científicas
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
DOS PASSOS, GIORDANI RODRIGUES; OLIVEIRA, LUANA MICHELLI; DA COSTA, BRUNA KLEIN; APOSTOLOS-PEREIRA, SAMIRA LUISA; CALLEGARO, DAGOBERTO; FUJIHARA, KAZUO; SATO, DOUGLAS KAZUTOSHI. MOG-IgG-Associated Optic Neuritis, Encephalitis, and Myelitis: Lessons Learned From Neuromyelitis Optica Spectrum Disorder. FRONTIERS IN NEUROLOGY, v. 9, . (15/23968-6)
OLIVEIRA, LUANA MICHELLI; APOSTOLOS-PEREIRA, SAMIRA LUISA; PITOMBEIRA, MILENA SALES; BRUEL TORRETTA, PEDRO HENRIQUE; CALLEGARO, DAGOBERTO; SATO, DOUGLAS KAZUTOSHI. Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and myelitis. MULTIPLE SCLEROSIS, v. 25, n. 14, p. 1907-1914, . (15/23968-6)
Publicações acadêmicas
(Referências obtidas automaticamente das Instituições de Ensino e Pesquisa do Estado de São Paulo)
SALLES, Luana Michelli Oliveira de Paula. Longitudinal study of clinical, laboratorial and imaging aspects of MOG-IgG positive patients. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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