Linically suspected neuromyelitis optica associated to anti-MOG antibodies

Abstract

Since MOG antibody has been described, it was associated with many demyelinated diseases like ADEM, pediatric MS, NMO, Neuromyelitis Optica Spectrum Disorders (NMOSD), isolated myelitis and optic neuritis. The role of MOG antibodies is yet unclear. Although MOG antibodies have been shown to be potentially pathogenic and to efficiently activate complement in-vitro small scale studies, earlier studies used ELISA and western-blot, so it is possible that less specific MOG antibody assays have added some confounding factors into some previous studies. Currently, the experience with cell-based assays to test MOG antibodies sounds promising to evaluate the utility of MOG antibodies as a biomarker in the clinical practice. Further studies evaluating the recognition of MOG epitopes and pathogenicity by these antibodies including a broader number of inflammatory idiopathic CNS disorders, such as MS, ADEM, AQP4 antibody seronegative NMOSD, and isolated optic neuritis may clarify whether patients with MOG antibodies may have a common immunopathological mechanism or multiple immune dysfunctions resulting in the same autoantibody. In our work we aim to describe optic neuritis ON, Longitudinally Extensive Transverse Myelitis (LETM), MOSD, NMO associated to MOG antibodies and describe the disease phenothype (recurrent x single attack) associated to MOG antibodies and antibodies titles bnehavior. (AU)