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Influence of obesity on the periodontal tissues remodeling induced by orthodontic mechanical force

Grant number: 16/00732-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2016
Effective date (End): March 31, 2018
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Joni Augusto Cirelli
Grantee:Camila Chierici Marcantonio
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The aim of this research project is to evaluate the effect of obesity on rat periodontal tissues remodeling induced by mechanical orthodontic force. A total of 40 rats will be distributed into 4 experimental groups: control (C), obesity induction (O), orthodontic movement induction (M), and obesity induction followed by orthodontic movement (OM). The animals will be sacrificed 10 days after movement beginning. Alveolar bone loss will be measured by micro-computed tomography analysis. The proportion of the following tissue components: collagen fibers, fibroblasts, inflammatory cells and blood vessels will be determined histologically by stereometry. Furthermore, the gene expression and the synthesis of proteins associated with obesity such as leptin, visfatin, resistin, adiponectin, IL-1², TNF-±, and IL-6 will be evaluated respectively by qPCR and immunohistochemistry. All data will be evaluated, and then subjected to normality test. Then, appropriate statistical tests for comparisons between groups will be used. For all tests, a 5% significance level will be adopted. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCANTONIO, CAMILA CHIERICI; LOPES, MARIA EDUARDA SCORDAMAIA; MOFATTO, LUCIANA SOUTO; SALMON, CRISTIANE RIBEIRO; DESCHNER, JAMES; NOCITI-JUNIOR, FRANCISCO HUMBERTO; CIRELLI, JONI AUGUSTO; NOGUEIRA, ANDRESSA VILAS BOAS. Obesity affects the proteome profile of periodontal ligament submitted to mechanical forces induced by orthodontic tooth movement in rats. JOURNAL OF PROTEOMICS, v. 263, p. 10-pg., . (16/00732-0, 14/20715-7, 17/07137-2, 18/25811-5)
MARCANTONIO, CAMILA CHIERICI; NOGUEIRA, ANDRESSA VILAS BOAS; LEGUIZAM, NATALIA DA PONTE; DE MOLON, RAFAEL SCAF; LOPES, MARIA EDUARDA SCORDAMAIA; SILVA, RENATA CRISTINA LIMA; CERRI, PAULO SERGIO; DESCHNER, JAMES; CIRELLI, JONI AUGUSTO. Effects of obesity on periodontal tissue remodeling during orthodontic movement. AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, v. 159, n. 4, p. 11-pg., . (16/00732-0, 14/20715-7, 17/01358-7, 17/07137-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARCANTONIO, Camila Chierici. Influence of obesity on the periodontal tissues remodeling induced by orthodontic mechanical force. 2018. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.

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