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MECHANISMS OF COMMUNICATION BETWEEN CENTRAL NERVOUS SYSTEM AND KIDNEY IN EXPERIMENTAL DIABETES MELLITUS

Grant number: 14/26387-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2016
Effective date (End): September 30, 2018
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Ruy Ribeiro de Campos Junior
Grantee:Tales Lyra de Oliveira
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Diabetes mellitus (DM) is a syndrome with multiple etiology characterized by the presence of inappropriate hyperglycemia caused by lack of insulin and/or its failure to properly exercise its effects. The impact of the disease as a public health problem stems not only from their clinical problems directly related to hyperglycemia, but mainly by the functional changes that occur in different organs and systems, resulting from chronic metabolic disorder. These complications, it is noteworthy that diabetic nephropathy is the most common etiology of chronic kidney disease in Western countries being associated with the highest mortality rate. In the model streptozotocin-induced diabetic rats has been shown that renal sympathetic nerve activity is paradoxically enhanced in relation to other areas of the body. It is also known that this model of DM has increased oxidative stress and activation of the renin-angiotensin system (RAS) and that these factors may be involved in autonomic dysfunction in DM. Therefore, this project aims to assess the level of sympathetic postganglionic basal activity (tonic and reflex) of renal and lumbar nerves and their correlation with the activity of the phrenic nerve, since the respiratory activity strongly influences vasomotor sympathetic activity. In this way, we intend to investigate whether there is is a topographic or preferred setting of sympathetic vasomotor activity and respiratory drive in DM. At the same time, will be evaluated the glutamatergic and angiotensinergic actions in rostral ventrolateral medulla, considered one of the most important regions of the brain involved in the control of sympathetic vasomotor activity. In addition, we will evaluate the renal and central oxidative stress and RAS by molecular biology approaches. In another series of experiments we will investigate the role of renal denervation in the sympathetic balance, cardiovascular, oxidative stress and metabolic parameters in control and diabetic rats. Thus, we aimed to improve understanding of the various mechanisms involved in the sympathetic vasomotor autonomic control in DM.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, TALES LYRA; LINCEVICIUS, GISELE SILVERIO; SHIMOURA, CAROLINE GUSSON; SIMOES-SATO, ALEX YURI; GARCIA, MICHELLE LOUVAES; BERGAMASCHI, CASSIA T.; CAMPOS, RUY R.. Effects of renal denervation on cardiovascular, metabolic and renal functions in streptozotocin-induced diabetic rats. Life Sciences, v. 278, . (14/26387-1, 19/25295-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.