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Functional biomembranes based on peptides and bottlebrush polymers to tissue engineering

Grant number: 16/00575-1
Support Opportunities:Scholarships abroad - Research
Effective date (Start): July 01, 2016
Effective date (End): June 30, 2017
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Fernanda Roberta Marciano
Grantee:Fernanda Roberta Marciano
Host Investigator: Ali Khademhosseini
Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
Research place: Harvard University, Cambridge, United States  
Associated research grant:11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications, AP.JP


This BPE application is directly associated to an approved grant coordinator by the proponent (Young Researcher FAPESP project "Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications" (2011/20345-7)) and other two approved grants in which the proponent is an associated professor, follows: (i) FAPESP-MIT "Novel Nanobiomaterials Based on Tridimensional Peptides with Drug Delivery Properties to Tissue Engineering" (2014/50720-2) and (ii) Young Researcher FAPESP project "Development of Novel Polymeric Scaffolds by Electrospinning with Incorporated Vertically-Aligned Carbon Nanotubes and Nanohidroxyapatite for Bone Regeneration" (2011/17877-7). We have been use synthetic and commercial polymers, which precluded the development of new relevant nanobiomaterials for tissue engineering. During a short stage at MIT (FAPESP-MIT grant), the proponent learned how to develop new polymeric nano-architectures associated to peptides. In the present proposal, we will extend the FAPESP-MIT approved project, including Harvard University. The proponent will propose an association between peptides and bioreabsorbable polymers for functional biomembrane fabrication. Dr. Khademhosseini at Harvard University has a large experience and facilities to produce nanobiomaterials using bioprinting process and in vitro studies of these new nanobiomaterials. The proposed research stage scholarship will be very interesting to involve research's groups, because Laboratory of Biomedical Nanotechnology coordinated by this proponent have experience in polymer extrusion using electrospinning and rotary-jet spinning. Herein, the proponent is proposing to create an innovative technology for manufacturing functional biomembranes. It will be expected to develop a new three-dimensional nanobiomaterial with biomimetic properties that improve bone tissue regeneration and reduce the inflammation process. Biological in vitro and in vivo assays will be performed to rapid translation of our novel materials. Thus, following the methodology of this project, it is expected that this new nanomaterial can: accelerate the regeneration of bone tissue, recruit stem cells, reduce the risk of bacterial contamination and be sufficiently low-cost to be translated into clinical regenerative medicine applications. In addition, it will be expected with the establishment of this proposal that it can help the proponent to expand the research line at University of Vale do Paraiba, seeking the production of new biomimetic materials based on functional peptide nanobiomaterials. Finally, after the proponent come back to Brazil, it is expected to engage undergraduate students, master's and doctoral degree from Materials Science and Biomedical Engineering programs in this new research line. This can facilitate the increase internationalization of graduate and undergraduate programs involving nanobiomaterials applied to tissue engineering researches at University of Vale do Paraiba. (AU)

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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES, BRUNO V. M.; RAZZINO, CLAUDIA A.; OLIVEIRA, FRANCILIO DE CARVALHO; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.. On the design and properties of scaffolds based on vertically aligned carbon nanotubes transferred onto electrospun poly (lactic acid) fibers. MATERIALS & DESIGN, v. 127, p. 183-192, . (15/08523-8, 11/17877-7, 15/09697-0, 16/00575-1)
RICCI, R.; LEITE, N. C. S.; DA-SILVA, N. S.; PACHECO-SOARES, C.; CANEVARI, R. A.; MARCIANO, F. R.; WEBSTER, T. J.; LOBO, A. O.. Graphene oxide nanoribbons as nanomaterial for bone regeneration: Effects on cytotoxicity, gene expression and bactericidal effect. Materials Science & Engineering C-Materials for Biological Applications, v. 78, p. 341-348, . (11/17877-7, 11/20345-7, 13/14464-9, 13/20054-8, 15/09697-0, 09/18440-1, 16/00575-1)
DIAS, VANESSA; MACIEL, HOMERO; FRAGA, MARIANA; LOBO, ANDERSON O.; PESSOA, RODRIGO; MARCIANO, FERNANDA R.. Atomic Layer Deposited TiO2 and Al2O3 Thin Films as Coatings for Aluminum Food Packaging Application. MATERIALS, v. 12, n. 4, . (14/18139-8, 11/50773-0, 11/17877-7, 12/15857-1, 11/20345-7, 16/00575-1, 15/05956-0, 15/09697-0, 18/01265-1, 15/10876-6)
LOPES, F. S.; OLIVEIRA, J. R.; MILANI, J.; OLIVEIRA, L. D.; MACHADO, J. P. B.; TRAVA-AIROLDI, V. J.; LOBO, A. O.; MARCIANO, F. R.. Biomineralized diamond-like carbon films with incorporated titanium dioxide nanoparticles improved bioactivity properties and reduced biofilm formation. Materials Science & Engineering C-Materials for Biological Applications, v. 81, p. 373-379, . (12/15857-1, 11/17877-7, 11/20345-7, 14/11491-8, 15/09697-0, 16/00575-1)
SILVA, EDMUNDO; REIS DE VASCONCELLOS, LUANA MAROTTA; RODRIGUES, BRUNO V. M.; DOS SANTOS, DANILO MARTINS; CAMPANA-FILHO, SERGIO P.; MARCIANO, FERNANDA ROBERTA; WEBSTER, THOMAS J.; LOBO, ANDERSON OLIVEIRA. PDLLA honeycomb-like scaffolds with a high loading of superhydrophilic graphene/multi-walled carbon nanotubes promote osteoblast in vitro functions and guided in vivo bone regeneration. Materials Science & Engineering C-Materials for Biological Applications, v. 73, p. 31-39, . (11/17877-7, 11/20345-7, 15/09697-0, 15/08523-8, 16/00575-1)
RODRIGUES, BRUNO V. M.; RAZZINO, CLAUDIA A.; OLIVEIRA, FRANCILIO DE CARVALHO; MARCIANO, FERNANDA R.; LOBO, ANDERSON O.. On the design and properties of scaffolds based on vertically aligned carbon nanotubes transferred onto electrospun poly (lactic acid) fibers. MATERIALS & DESIGN, v. 127, p. 10-pg., . (15/09697-0, 16/00575-1, 15/08523-8, 11/17877-7)
STOCCO, T. D.; RODRIGUES, B. V. M.; MARCIANO, F. R.; LOBO, A. O.. Design of a novel electrospinning setup for the fabrication of biomimetic scaffolds for meniscus tissue engineering applications. Materials Letters, v. 196, p. 221-224, . (11/17877-7, 15/08523-8, 11/20345-7, 16/00575-1, 15/09697-0)
SILVA SOARES, LUIS EDUARDO; NAHORNY, SIDNEI; BRAGA, VIVIAN DE FARIA; MARCIANO, FERNANDA ROBERTA; BHATTACHARJEE, TANMOY T.; LOBO, ANDERSON OLIVEIRA. Raman spectroscopy-multivariate analysis related to morphological surface features on nanomaterials applied for dentin coverage. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 228, . (11/20345-7, 11/17877-7, 16/00575-1, 13/11192-8, 14/21587-2, 15/09697-0, 14/02163-7)
RODRIGUES, BRUNO V. M.; DIAS, VANESSA M.; FRAGA, MARIANA A.; DA SILVA SOBRINHO, ARGEMIRO S.; LOBO, ANDERSON O.; MACIEL, HOMERO S.; PESSOA, RODRIGO S.. Atomic layer deposition of TiO2 thin films on electrospun poly (butylene adipate-co-terephthalate) fibers: Freestanding TiO2 nanostructures via polymer carbonization. MATERIALS TODAY-PROCEEDINGS, v. 14, p. 7-pg., . (15/10876-6, 17/18826-3, 15/09697-0, 11/50773-0, 12/15857-1, 11/20345-7, 16/00575-1, 15/05956-0, 18/01265-1)
NAHORNY, SIDNEI; ZANIN, HUDSON; CHRISTINO, VINIE ABREU; MARCIANO, FERNANDA ROBERTA; OLIVEIRA LOBO, ANDERSON; SILVA SOARES, LUIS EDUARDO. Multi-walled carbon nanotubes/graphene oxide hybrid and nanohydroxyapatite composite: A novel coating to prevent dentin erosion. Materials Science & Engineering C-Materials for Biological Applications, v. 79, p. 199-208, . (14/21587-2, 11/17877-7, 11/20345-7, 15/50093-0, 13/20825-4, 14/02163-7, 15/09697-0, 13/11192-8, 16/00575-1)
PESSOA, R. S.; DOS SANTOS, V. P.; CARDOSO, S. B.; DORIA, A. C. O. C.; FIGUEIRA, F. R.; RODRIGUES, B. V. M.; TESTONI, G. E.; FRAGA, M. A.; MARCIANO, F. R.; LOBO, A. O.; et al. TiO2 coatings via atomic layer deposition on polyurethane and polydimethylsiloxane substrates: Properties and effects on C. albicans growth and inactivation process. Applied Surface Science, v. 422, p. 73-84, . (11/50773-0, 12/15857-1, 11/17877-7, 11/20345-7, 15/10876-6, 15/09697-0, 15/08523-8, 16/00575-1, 15/05956-0)
SALLES, GEISA NOGUEIRA; DOS SANTOS PEREIRA, FERNANDA APARECIDA; PACHECO-SOARES, CRISTINA; MARCIANO, FERNANDA ROBERTA; HOLSCHER, CHRISTIAN; WEBSTER, THOMAS J.; LOBO, ANDERSON OLIVEIRA. A Novel Bioresorbable Device as a Controlled Release System for Protecting Cells from Oxidative Stress from Alzheimer's Disease. Molecular Neurobiology, v. 54, n. 9, p. 6827-6838, . (11/17877-7, 11/20345-7, 15/09697-0, 14/20561-0, 16/00575-1)
SANTANA-MELO, GABRIELA F.; RODRIGUES, BRUNO V. M.; DA SILVA, EDMUNDO; RICCI, RITCHELLI; MARCIANO, FERNANDA R.; WEBSTER, THOMAS J.; VASCONCELLOS, LUANA M. R.; LOBO, ANDERSON O.. Electrospun ultrathin PBAT/nHAp fibers influenced the in vitro and in vivo osteogenesis and improved the mechanical properties of neoformed bone. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 155, p. 544-552, . (11/17877-7, 11/20345-7, 15/09697-0, 15/08523-8, 16/00575-1)

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