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Identification of infectious agents in post-heart transplant endomyocardial biopsy of patients with idiopathic dilated cardiomyopathy and lymphocytic myocarditis

Grant number: 15/25786-2
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2016
Effective date (End): March 31, 2017
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal researcher:Maria de Lourdes Higuchi
Grantee:Jaqueline de Jesus Pereira
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Heart failure (HF) is a major problem of global public health, and the lack of a deeper pathogenic understanding of the causing diseases is the greatest difficulty for treatment's choice, especially of Idiopathic Dilated Cardiomyopathy (DCM). Objectives: Verify if immunosuppressive therapy administered to transplant patients to prevent organ rejection is associated with the increase of infectious agents compared to those present in the explanted heart, verify possible role of these agents in inflammation related to rejection and diagnose possible co-infections in explanted hearts with CMD. Methods: Immunohistochemistry reactions will be performed to study primary antibodies against inflammatory cells: T (CD3, CD4, CD8 and CD45), B (CD20) and macrophages (CD68); expression of HLA-DR/DP/DQ and infectious agents: Chlamydia pneumoniae, Mycoplasma pneumoniae and Borrelia burgerdorferi and cardiotropic virus (Enterovirus, Parvovirus, Hepatitis C virus, Hepatitis B virus, Epstein-Barr virus, adenovirus, human herpesvirus 1 2 and 6) in endomyocardial biopsies. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREIRA, JAQUELINE DE JESUS; IKEGAMI, RENATA NISHIYAMA; KAWAKAMI, JOYCE TIYEKO; GARAVELO, SHERRIRA MENEZES; REIS, MARCIA MARTINS; PALOMINO, SUELY APARECIDA PINHEIRO; MANGINI, SANDRIGO; MORENO, CAMILA RODRIGUES; DE BARROS, SAMAR FRESCHI; SOUZA, ALINE RODRIGUES; et al. istinct Microbial Communities in Dilated Cardiomyopathy Explanted Hearts Are Associated With Different Myocardial Rejection Outcome. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, . (15/25786-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEREIRA, Jaqueline de Jesus. Infectious agents in heart of patients with idiopathic dilated cardiomyopathy: potential relation with rejection of cardiac transplantation. 2019. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.